Cargando…
SUMOylation Connects Cell Stress Responses and Inflammatory Control: Lessons From the Gut as a Model Organ
Conjugation with the small ubiquitin-like modifier (SUMO) constitutes a key post-translational modification regulating the stability, activity, and subcellular localization of its target proteins. However, the vast numbers of identified SUMO substrates obscure a clear view on the function of SUMOyla...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933481/ https://www.ncbi.nlm.nih.gov/pubmed/33679811 http://dx.doi.org/10.3389/fimmu.2021.646633 |
_version_ | 1783660620765200384 |
---|---|
author | Karhausen, Jörn Ulloa, Luis Yang, Wei |
author_facet | Karhausen, Jörn Ulloa, Luis Yang, Wei |
author_sort | Karhausen, Jörn |
collection | PubMed |
description | Conjugation with the small ubiquitin-like modifier (SUMO) constitutes a key post-translational modification regulating the stability, activity, and subcellular localization of its target proteins. However, the vast numbers of identified SUMO substrates obscure a clear view on the function of SUMOylation in health and disease. This article presents a comprehensive review on the physiological relevance of SUMOylation by discussing how global SUMOylation levels—rather than specific protein SUMOylation—shapes the immune response. In particular, we highlight the growing body of work on SUMOylation in intestinal pathologies, because of the unique metabolic, infectious, and inflammatory challenges of this organ. Recent studies show that global SUMOylation can help restrain detrimental inflammation while maintaining immune defenses and tissue integrity. These results warrant further efforts to develop new therapeutic tools and strategies to control SUMOylation in infectious and inflammatory disorders. |
format | Online Article Text |
id | pubmed-7933481 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79334812021-03-06 SUMOylation Connects Cell Stress Responses and Inflammatory Control: Lessons From the Gut as a Model Organ Karhausen, Jörn Ulloa, Luis Yang, Wei Front Immunol Immunology Conjugation with the small ubiquitin-like modifier (SUMO) constitutes a key post-translational modification regulating the stability, activity, and subcellular localization of its target proteins. However, the vast numbers of identified SUMO substrates obscure a clear view on the function of SUMOylation in health and disease. This article presents a comprehensive review on the physiological relevance of SUMOylation by discussing how global SUMOylation levels—rather than specific protein SUMOylation—shapes the immune response. In particular, we highlight the growing body of work on SUMOylation in intestinal pathologies, because of the unique metabolic, infectious, and inflammatory challenges of this organ. Recent studies show that global SUMOylation can help restrain detrimental inflammation while maintaining immune defenses and tissue integrity. These results warrant further efforts to develop new therapeutic tools and strategies to control SUMOylation in infectious and inflammatory disorders. Frontiers Media S.A. 2021-02-19 /pmc/articles/PMC7933481/ /pubmed/33679811 http://dx.doi.org/10.3389/fimmu.2021.646633 Text en Copyright © 2021 Karhausen, Ulloa and Yang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Karhausen, Jörn Ulloa, Luis Yang, Wei SUMOylation Connects Cell Stress Responses and Inflammatory Control: Lessons From the Gut as a Model Organ |
title | SUMOylation Connects Cell Stress Responses and Inflammatory Control: Lessons From the Gut as a Model Organ |
title_full | SUMOylation Connects Cell Stress Responses and Inflammatory Control: Lessons From the Gut as a Model Organ |
title_fullStr | SUMOylation Connects Cell Stress Responses and Inflammatory Control: Lessons From the Gut as a Model Organ |
title_full_unstemmed | SUMOylation Connects Cell Stress Responses and Inflammatory Control: Lessons From the Gut as a Model Organ |
title_short | SUMOylation Connects Cell Stress Responses and Inflammatory Control: Lessons From the Gut as a Model Organ |
title_sort | sumoylation connects cell stress responses and inflammatory control: lessons from the gut as a model organ |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933481/ https://www.ncbi.nlm.nih.gov/pubmed/33679811 http://dx.doi.org/10.3389/fimmu.2021.646633 |
work_keys_str_mv | AT karhausenjorn sumoylationconnectscellstressresponsesandinflammatorycontrollessonsfromthegutasamodelorgan AT ulloaluis sumoylationconnectscellstressresponsesandinflammatorycontrollessonsfromthegutasamodelorgan AT yangwei sumoylationconnectscellstressresponsesandinflammatorycontrollessonsfromthegutasamodelorgan |