Cargando…

The emerging roles of the macular pigment carotenoids throughout the lifespan and in prenatal supplementation

Since the publication of the Age-Related Eye Disease Study 2 (AREDS2) in 2013, the macular pigment carotenoids lutein (L) and zeaxanthin (Z) have become well known to both the eye care community and the public. It is a fascinating aspect of evolution that primates have repurposed photoprotective pig...

Descripción completa

Detalles Bibliográficos
Autores principales: Bernstein, Paul S., Arunkumar, Ranganathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933486/
https://www.ncbi.nlm.nih.gov/pubmed/32709621
http://dx.doi.org/10.1194/jlr.TR120000956
_version_ 1783660621692141568
author Bernstein, Paul S.
Arunkumar, Ranganathan
author_facet Bernstein, Paul S.
Arunkumar, Ranganathan
author_sort Bernstein, Paul S.
collection PubMed
description Since the publication of the Age-Related Eye Disease Study 2 (AREDS2) in 2013, the macular pigment carotenoids lutein (L) and zeaxanthin (Z) have become well known to both the eye care community and the public. It is a fascinating aspect of evolution that primates have repurposed photoprotective pigments and binding proteins from plants and insects to protect and enhance visual acuity. Moreover, utilization of these plant-derived nutrients has been widely embraced for preventing vision loss from age-related macular degeneration. More recently, there has been growing awareness that these nutrients can also play a role in improving visual performance in adults. On the other hand, the potential benefits of L and Z supplementation at very young ages have been underappreciated. In this review, we examine the biochemical mechanisms and supportive data for L and Z supplementation throughout the lifespan, with particular emphasis on prenatal supplementation. We propose that prenatal nutritional recommendations may aim at improving maternal and infant carotenoid status. Prenatal supplementation with L and Z might enhance infant visual development and performance and may even prevent retinopathy of prematurity, possibilities that should be examined in future clinical studies.
format Online
Article
Text
id pubmed-7933486
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher American Society for Biochemistry and Molecular Biology
record_format MEDLINE/PubMed
spelling pubmed-79334862021-03-19 The emerging roles of the macular pigment carotenoids throughout the lifespan and in prenatal supplementation Bernstein, Paul S. Arunkumar, Ranganathan J Lipid Res Thematic Review Series Since the publication of the Age-Related Eye Disease Study 2 (AREDS2) in 2013, the macular pigment carotenoids lutein (L) and zeaxanthin (Z) have become well known to both the eye care community and the public. It is a fascinating aspect of evolution that primates have repurposed photoprotective pigments and binding proteins from plants and insects to protect and enhance visual acuity. Moreover, utilization of these plant-derived nutrients has been widely embraced for preventing vision loss from age-related macular degeneration. More recently, there has been growing awareness that these nutrients can also play a role in improving visual performance in adults. On the other hand, the potential benefits of L and Z supplementation at very young ages have been underappreciated. In this review, we examine the biochemical mechanisms and supportive data for L and Z supplementation throughout the lifespan, with particular emphasis on prenatal supplementation. We propose that prenatal nutritional recommendations may aim at improving maternal and infant carotenoid status. Prenatal supplementation with L and Z might enhance infant visual development and performance and may even prevent retinopathy of prematurity, possibilities that should be examined in future clinical studies. American Society for Biochemistry and Molecular Biology 2021-02-06 /pmc/articles/PMC7933486/ /pubmed/32709621 http://dx.doi.org/10.1194/jlr.TR120000956 Text en © 2021 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Thematic Review Series
Bernstein, Paul S.
Arunkumar, Ranganathan
The emerging roles of the macular pigment carotenoids throughout the lifespan and in prenatal supplementation
title The emerging roles of the macular pigment carotenoids throughout the lifespan and in prenatal supplementation
title_full The emerging roles of the macular pigment carotenoids throughout the lifespan and in prenatal supplementation
title_fullStr The emerging roles of the macular pigment carotenoids throughout the lifespan and in prenatal supplementation
title_full_unstemmed The emerging roles of the macular pigment carotenoids throughout the lifespan and in prenatal supplementation
title_short The emerging roles of the macular pigment carotenoids throughout the lifespan and in prenatal supplementation
title_sort emerging roles of the macular pigment carotenoids throughout the lifespan and in prenatal supplementation
topic Thematic Review Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933486/
https://www.ncbi.nlm.nih.gov/pubmed/32709621
http://dx.doi.org/10.1194/jlr.TR120000956
work_keys_str_mv AT bernsteinpauls theemergingrolesofthemacularpigmentcarotenoidsthroughoutthelifespanandinprenatalsupplementation
AT arunkumarranganathan theemergingrolesofthemacularpigmentcarotenoidsthroughoutthelifespanandinprenatalsupplementation
AT bernsteinpauls emergingrolesofthemacularpigmentcarotenoidsthroughoutthelifespanandinprenatalsupplementation
AT arunkumarranganathan emergingrolesofthemacularpigmentcarotenoidsthroughoutthelifespanandinprenatalsupplementation