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Copper and Cobalt Ions Released from Metal Oxide Nanoparticles Trigger Skin Sensitization
Human skins are exposed to nanomaterials in everyday life from various sources such as nanomaterial-containing cosmetics, air pollutions, and industrial nanomaterials. Nanomaterials comprising metal haptens raises concerns about the skin sensitization to nanomaterials. In this study, we evaluated th...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933575/ https://www.ncbi.nlm.nih.gov/pubmed/33679407 http://dx.doi.org/10.3389/fphar.2021.627781 |
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author | Kim, Sung-Hyun Lee, Jin Hee Jung, Kikyung Yang, Jun-Young Shin, Hyo-Sook Lee, Jeong Pyo Jeong, Jayoung Oh, Jae-Ho Lee, Jong Kwon |
author_facet | Kim, Sung-Hyun Lee, Jin Hee Jung, Kikyung Yang, Jun-Young Shin, Hyo-Sook Lee, Jeong Pyo Jeong, Jayoung Oh, Jae-Ho Lee, Jong Kwon |
author_sort | Kim, Sung-Hyun |
collection | PubMed |
description | Human skins are exposed to nanomaterials in everyday life from various sources such as nanomaterial-containing cosmetics, air pollutions, and industrial nanomaterials. Nanomaterials comprising metal haptens raises concerns about the skin sensitization to nanomaterials. In this study, we evaluated the skin sensitization of nanomaterials comparing metal haptens in vivo and in vitro. We selected five metal oxide NPs, containing copper oxide, cobalt monoxide, cobalt oxide, nickel oxide, or titanium oxide, and two types of metal chlorides (CoCl(2) and CuCl(2)), to compare the skin sensitization abilities between NPs and the constituent metals. The materials were applied to KeratinoSens(TM) cells for imitated skin-environment setting, and luciferase induction and cytotoxicity were evaluated at 48 h post-incubation. In addition, the response of metal oxide NPs was confirmed in lymph node of BALB/C mice via an in vivo method. The results showed that CuO and CoO NPs induce a similar pattern of positive luciferase induction and cytotoxicity compared to the respective metal chlorides; Co(3)O(4), NiO, and TiO(2) induced no such response. Collectively, the results implied fast-dissolving metal oxide (CuO and CoO) NPs release their metal ion, inducing skin sensitization. However, further investigations are required to elucidate the mechanism underlying NP-induced skin sensitization. Based on ion chelation data, metal ion release was confirmed as the major “factor” for skin sensitization. |
format | Online Article Text |
id | pubmed-7933575 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79335752021-03-06 Copper and Cobalt Ions Released from Metal Oxide Nanoparticles Trigger Skin Sensitization Kim, Sung-Hyun Lee, Jin Hee Jung, Kikyung Yang, Jun-Young Shin, Hyo-Sook Lee, Jeong Pyo Jeong, Jayoung Oh, Jae-Ho Lee, Jong Kwon Front Pharmacol Pharmacology Human skins are exposed to nanomaterials in everyday life from various sources such as nanomaterial-containing cosmetics, air pollutions, and industrial nanomaterials. Nanomaterials comprising metal haptens raises concerns about the skin sensitization to nanomaterials. In this study, we evaluated the skin sensitization of nanomaterials comparing metal haptens in vivo and in vitro. We selected five metal oxide NPs, containing copper oxide, cobalt monoxide, cobalt oxide, nickel oxide, or titanium oxide, and two types of metal chlorides (CoCl(2) and CuCl(2)), to compare the skin sensitization abilities between NPs and the constituent metals. The materials were applied to KeratinoSens(TM) cells for imitated skin-environment setting, and luciferase induction and cytotoxicity were evaluated at 48 h post-incubation. In addition, the response of metal oxide NPs was confirmed in lymph node of BALB/C mice via an in vivo method. The results showed that CuO and CoO NPs induce a similar pattern of positive luciferase induction and cytotoxicity compared to the respective metal chlorides; Co(3)O(4), NiO, and TiO(2) induced no such response. Collectively, the results implied fast-dissolving metal oxide (CuO and CoO) NPs release their metal ion, inducing skin sensitization. However, further investigations are required to elucidate the mechanism underlying NP-induced skin sensitization. Based on ion chelation data, metal ion release was confirmed as the major “factor” for skin sensitization. Frontiers Media S.A. 2021-02-19 /pmc/articles/PMC7933575/ /pubmed/33679407 http://dx.doi.org/10.3389/fphar.2021.627781 Text en Copyright © 2021 Kim, Lee, Jung, Yang, Shin, Lee, Jeong, Oh and Lee. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Kim, Sung-Hyun Lee, Jin Hee Jung, Kikyung Yang, Jun-Young Shin, Hyo-Sook Lee, Jeong Pyo Jeong, Jayoung Oh, Jae-Ho Lee, Jong Kwon Copper and Cobalt Ions Released from Metal Oxide Nanoparticles Trigger Skin Sensitization |
title | Copper and Cobalt Ions Released from Metal Oxide Nanoparticles Trigger Skin Sensitization |
title_full | Copper and Cobalt Ions Released from Metal Oxide Nanoparticles Trigger Skin Sensitization |
title_fullStr | Copper and Cobalt Ions Released from Metal Oxide Nanoparticles Trigger Skin Sensitization |
title_full_unstemmed | Copper and Cobalt Ions Released from Metal Oxide Nanoparticles Trigger Skin Sensitization |
title_short | Copper and Cobalt Ions Released from Metal Oxide Nanoparticles Trigger Skin Sensitization |
title_sort | copper and cobalt ions released from metal oxide nanoparticles trigger skin sensitization |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933575/ https://www.ncbi.nlm.nih.gov/pubmed/33679407 http://dx.doi.org/10.3389/fphar.2021.627781 |
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