Urine proteome of COVID-19 patients

The atypical pneumonia (COVID-19) caused by SARS-CoV-2 is a serious threat to global public health. However, early detection and effective prediction of patients with mild to severe symptoms remain challenging. The proteomic profiling of urine samples from healthy individuals, mild and severe COVID-...

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Autores principales: Li, Yanchang, Wang, Yihao, Liu, Huiying, Sun, Wei, Ding, Baoqing, Zhao, Yinghua, Chen, Peiru, Zhu, Li, Li, Zhaodi, Li, Naikang, Chang, Lei, Wang, Hengliang, Bai, Changqing, Xu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933783/
https://www.ncbi.nlm.nih.gov/pubmed/33688631
http://dx.doi.org/10.1016/j.urine.2021.02.001
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author Li, Yanchang
Wang, Yihao
Liu, Huiying
Sun, Wei
Ding, Baoqing
Zhao, Yinghua
Chen, Peiru
Zhu, Li
Li, Zhaodi
Li, Naikang
Chang, Lei
Wang, Hengliang
Bai, Changqing
Xu, Ping
author_facet Li, Yanchang
Wang, Yihao
Liu, Huiying
Sun, Wei
Ding, Baoqing
Zhao, Yinghua
Chen, Peiru
Zhu, Li
Li, Zhaodi
Li, Naikang
Chang, Lei
Wang, Hengliang
Bai, Changqing
Xu, Ping
author_sort Li, Yanchang
collection PubMed
description The atypical pneumonia (COVID-19) caused by SARS-CoV-2 is a serious threat to global public health. However, early detection and effective prediction of patients with mild to severe symptoms remain challenging. The proteomic profiling of urine samples from healthy individuals, mild and severe COVID-19 positive patients with comorbidities can be clearly differentiated. Multiple pathways have been compromised after the COVID-19 infection, including the dysregulation of complement activation, platelet degranulation, lipoprotein metabolic process and response to hypoxia. This study demonstrates the COVID-19 pathophysiology related molecular alterations could be detected in the urine and the potential application in auxiliary diagnosis of COVID-19.
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spelling pubmed-79337832021-03-05 Urine proteome of COVID-19 patients Li, Yanchang Wang, Yihao Liu, Huiying Sun, Wei Ding, Baoqing Zhao, Yinghua Chen, Peiru Zhu, Li Li, Zhaodi Li, Naikang Chang, Lei Wang, Hengliang Bai, Changqing Xu, Ping Urine (Amst) Article The atypical pneumonia (COVID-19) caused by SARS-CoV-2 is a serious threat to global public health. However, early detection and effective prediction of patients with mild to severe symptoms remain challenging. The proteomic profiling of urine samples from healthy individuals, mild and severe COVID-19 positive patients with comorbidities can be clearly differentiated. Multiple pathways have been compromised after the COVID-19 infection, including the dysregulation of complement activation, platelet degranulation, lipoprotein metabolic process and response to hypoxia. This study demonstrates the COVID-19 pathophysiology related molecular alterations could be detected in the urine and the potential application in auxiliary diagnosis of COVID-19. The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. 2020 2021-03-05 /pmc/articles/PMC7933783/ /pubmed/33688631 http://dx.doi.org/10.1016/j.urine.2021.02.001 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Li, Yanchang
Wang, Yihao
Liu, Huiying
Sun, Wei
Ding, Baoqing
Zhao, Yinghua
Chen, Peiru
Zhu, Li
Li, Zhaodi
Li, Naikang
Chang, Lei
Wang, Hengliang
Bai, Changqing
Xu, Ping
Urine proteome of COVID-19 patients
title Urine proteome of COVID-19 patients
title_full Urine proteome of COVID-19 patients
title_fullStr Urine proteome of COVID-19 patients
title_full_unstemmed Urine proteome of COVID-19 patients
title_short Urine proteome of COVID-19 patients
title_sort urine proteome of covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933783/
https://www.ncbi.nlm.nih.gov/pubmed/33688631
http://dx.doi.org/10.1016/j.urine.2021.02.001
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