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Modeling SARS-CoV-2 infection in individuals with opioid use disorder with brain organoids
The COVID-19 pandemic has aggravated a preexisting epidemic: the opioid crisis. Much literature has shown that the circumstances imposed by COVID-19, such as social distancing regulations, medical and financial instability, and increased mental health issues, have been detrimental to those with opio...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934045/ https://www.ncbi.nlm.nih.gov/pubmed/33738089 http://dx.doi.org/10.1177/2041731420985299 |
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author | Willner, Moshe J Xiao, Yang Kim, Hye Sung Chen, Xuejing Xu, Bin Leong, Kam W |
author_facet | Willner, Moshe J Xiao, Yang Kim, Hye Sung Chen, Xuejing Xu, Bin Leong, Kam W |
author_sort | Willner, Moshe J |
collection | PubMed |
description | The COVID-19 pandemic has aggravated a preexisting epidemic: the opioid crisis. Much literature has shown that the circumstances imposed by COVID-19, such as social distancing regulations, medical and financial instability, and increased mental health issues, have been detrimental to those with opioid use disorder (OUD). In addition, unexpected neurological sequelae in COVID-19 patients suggest that COVID-19 compromises neuroimmunity, induces hypoxia, and causes respiratory depression, provoking similar effects as those caused by opioid exposure. Combined conditions of COVID-19 and OUD could lead to exacerbated complications. With limited human in vivo options to study these complications, we suggest that iPSC-derived brain organoid models may serve as a useful platform to investigate the physiological connection between COVID-19 and OUD. This mini-review highlights the advances of brain organoids in other neuropsychiatric and infectious diseases and suggests their potential utility for investigating OUD and COVID-19, respectively. |
format | Online Article Text |
id | pubmed-7934045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-79340452021-03-17 Modeling SARS-CoV-2 infection in individuals with opioid use disorder with brain organoids Willner, Moshe J Xiao, Yang Kim, Hye Sung Chen, Xuejing Xu, Bin Leong, Kam W J Tissue Eng Technological advances in 3D tissue and organ models The COVID-19 pandemic has aggravated a preexisting epidemic: the opioid crisis. Much literature has shown that the circumstances imposed by COVID-19, such as social distancing regulations, medical and financial instability, and increased mental health issues, have been detrimental to those with opioid use disorder (OUD). In addition, unexpected neurological sequelae in COVID-19 patients suggest that COVID-19 compromises neuroimmunity, induces hypoxia, and causes respiratory depression, provoking similar effects as those caused by opioid exposure. Combined conditions of COVID-19 and OUD could lead to exacerbated complications. With limited human in vivo options to study these complications, we suggest that iPSC-derived brain organoid models may serve as a useful platform to investigate the physiological connection between COVID-19 and OUD. This mini-review highlights the advances of brain organoids in other neuropsychiatric and infectious diseases and suggests their potential utility for investigating OUD and COVID-19, respectively. SAGE Publications 2021-02-26 /pmc/articles/PMC7934045/ /pubmed/33738089 http://dx.doi.org/10.1177/2041731420985299 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Technological advances in 3D tissue and organ models Willner, Moshe J Xiao, Yang Kim, Hye Sung Chen, Xuejing Xu, Bin Leong, Kam W Modeling SARS-CoV-2 infection in individuals with opioid use disorder with brain organoids |
title | Modeling SARS-CoV-2 infection in individuals with opioid use disorder with brain organoids |
title_full | Modeling SARS-CoV-2 infection in individuals with opioid use disorder with brain organoids |
title_fullStr | Modeling SARS-CoV-2 infection in individuals with opioid use disorder with brain organoids |
title_full_unstemmed | Modeling SARS-CoV-2 infection in individuals with opioid use disorder with brain organoids |
title_short | Modeling SARS-CoV-2 infection in individuals with opioid use disorder with brain organoids |
title_sort | modeling sars-cov-2 infection in individuals with opioid use disorder with brain organoids |
topic | Technological advances in 3D tissue and organ models |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934045/ https://www.ncbi.nlm.nih.gov/pubmed/33738089 http://dx.doi.org/10.1177/2041731420985299 |
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