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Assessment of Image Quality for Selective Intracoronary Contrast-Injected CT Angiography in a Hybrid Angio-CT System: A Feasibility Study in Swine

PURPOSE: To compare image quality in selective intracoronary contrast-injected computed tomography angiography (Selective-CTA) with that in conventional intravenous contrast-injected CTA (IV-CTA). MATERIALS AND METHODS: Six pigs (35 to 40 kg) underwent both IV-CTA using an intravenous injection (60...

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Autores principales: Ha, Seongmin, Jung, Sunghee, Park, Hyung-Bok, Shin, Sanghoon, Arsanjani, Reza, Hong, Youngtaek, Lee, Byoung Kwon, Jang, Yeonggul, Jeon, Byunghwan, Park, Se-Il, Shim, Hackjoon, Chang, Hyuk-Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934100/
https://www.ncbi.nlm.nih.gov/pubmed/33635009
http://dx.doi.org/10.3349/ymj.2021.62.3.200
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author Ha, Seongmin
Jung, Sunghee
Park, Hyung-Bok
Shin, Sanghoon
Arsanjani, Reza
Hong, Youngtaek
Lee, Byoung Kwon
Jang, Yeonggul
Jeon, Byunghwan
Park, Se-Il
Shim, Hackjoon
Chang, Hyuk-Jae
author_facet Ha, Seongmin
Jung, Sunghee
Park, Hyung-Bok
Shin, Sanghoon
Arsanjani, Reza
Hong, Youngtaek
Lee, Byoung Kwon
Jang, Yeonggul
Jeon, Byunghwan
Park, Se-Il
Shim, Hackjoon
Chang, Hyuk-Jae
author_sort Ha, Seongmin
collection PubMed
description PURPOSE: To compare image quality in selective intracoronary contrast-injected computed tomography angiography (Selective-CTA) with that in conventional intravenous contrast-injected CTA (IV-CTA). MATERIALS AND METHODS: Six pigs (35 to 40 kg) underwent both IV-CTA using an intravenous injection (60 mL) and Selective-CTA using an intracoronary injection (20 mL) through a guide-wire during/after percutaneous coronary intervention. Images of the common coronary artery were acquired. Scans were performed using a combined machine comprising an invasive coronary angiography suite and a 320-channel multi-slice CT scanner. Quantitative image quality parameters of CT attenuation, image noise, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), mean lumen diameter (MLD), and mean lumen area (MLA) were measured and compared. Qualitative analysis was performed using intraclass correlation coefficient (ICC), which was calculated for analysis of interobserver agreement. RESULTS: Quantitative image quality, determined by assessing the uniformity of CT attenuation (399.06 vs. 330.21, p<0.001), image noise (24.93 vs. 18.43, p<0.001), SNR (16.43 vs. 18.52, p=0.005), and CNR (11.56 vs. 13.46, p=0.002), differed significantly between IV-CTA and Selective-CTA. MLD and MLA showed no significant difference overall (2.38 vs. 2.44, p=0.068, 4.72 vs. 4.95, p=0.078). The density of contrast agent was significantly lower for selective-CTA (13.13 mg/mL) than for IV-CTA (400 mg/mL). Agreement between observers was acceptable (ICC=0.79±0.08). CONCLUSION: Our feasibility study in swine showed that compared to IV-CTA, Selective-CTA provides better image quality and requires less iodine contrast medium.
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spelling pubmed-79341002021-03-11 Assessment of Image Quality for Selective Intracoronary Contrast-Injected CT Angiography in a Hybrid Angio-CT System: A Feasibility Study in Swine Ha, Seongmin Jung, Sunghee Park, Hyung-Bok Shin, Sanghoon Arsanjani, Reza Hong, Youngtaek Lee, Byoung Kwon Jang, Yeonggul Jeon, Byunghwan Park, Se-Il Shim, Hackjoon Chang, Hyuk-Jae Yonsei Med J Original Article PURPOSE: To compare image quality in selective intracoronary contrast-injected computed tomography angiography (Selective-CTA) with that in conventional intravenous contrast-injected CTA (IV-CTA). MATERIALS AND METHODS: Six pigs (35 to 40 kg) underwent both IV-CTA using an intravenous injection (60 mL) and Selective-CTA using an intracoronary injection (20 mL) through a guide-wire during/after percutaneous coronary intervention. Images of the common coronary artery were acquired. Scans were performed using a combined machine comprising an invasive coronary angiography suite and a 320-channel multi-slice CT scanner. Quantitative image quality parameters of CT attenuation, image noise, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), mean lumen diameter (MLD), and mean lumen area (MLA) were measured and compared. Qualitative analysis was performed using intraclass correlation coefficient (ICC), which was calculated for analysis of interobserver agreement. RESULTS: Quantitative image quality, determined by assessing the uniformity of CT attenuation (399.06 vs. 330.21, p<0.001), image noise (24.93 vs. 18.43, p<0.001), SNR (16.43 vs. 18.52, p=0.005), and CNR (11.56 vs. 13.46, p=0.002), differed significantly between IV-CTA and Selective-CTA. MLD and MLA showed no significant difference overall (2.38 vs. 2.44, p=0.068, 4.72 vs. 4.95, p=0.078). The density of contrast agent was significantly lower for selective-CTA (13.13 mg/mL) than for IV-CTA (400 mg/mL). Agreement between observers was acceptable (ICC=0.79±0.08). CONCLUSION: Our feasibility study in swine showed that compared to IV-CTA, Selective-CTA provides better image quality and requires less iodine contrast medium. Yonsei University College of Medicine 2021-03-01 2021-02-15 /pmc/articles/PMC7934100/ /pubmed/33635009 http://dx.doi.org/10.3349/ymj.2021.62.3.200 Text en © Copyright: Yonsei University College of Medicine 2021 https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ha, Seongmin
Jung, Sunghee
Park, Hyung-Bok
Shin, Sanghoon
Arsanjani, Reza
Hong, Youngtaek
Lee, Byoung Kwon
Jang, Yeonggul
Jeon, Byunghwan
Park, Se-Il
Shim, Hackjoon
Chang, Hyuk-Jae
Assessment of Image Quality for Selective Intracoronary Contrast-Injected CT Angiography in a Hybrid Angio-CT System: A Feasibility Study in Swine
title Assessment of Image Quality for Selective Intracoronary Contrast-Injected CT Angiography in a Hybrid Angio-CT System: A Feasibility Study in Swine
title_full Assessment of Image Quality for Selective Intracoronary Contrast-Injected CT Angiography in a Hybrid Angio-CT System: A Feasibility Study in Swine
title_fullStr Assessment of Image Quality for Selective Intracoronary Contrast-Injected CT Angiography in a Hybrid Angio-CT System: A Feasibility Study in Swine
title_full_unstemmed Assessment of Image Quality for Selective Intracoronary Contrast-Injected CT Angiography in a Hybrid Angio-CT System: A Feasibility Study in Swine
title_short Assessment of Image Quality for Selective Intracoronary Contrast-Injected CT Angiography in a Hybrid Angio-CT System: A Feasibility Study in Swine
title_sort assessment of image quality for selective intracoronary contrast-injected ct angiography in a hybrid angio-ct system: a feasibility study in swine
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934100/
https://www.ncbi.nlm.nih.gov/pubmed/33635009
http://dx.doi.org/10.3349/ymj.2021.62.3.200
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