The number of methylated CpG sites within the MGMT promoter region linearly correlates with outcome in glioblastoma receiving alkylating agents

MGMT-promoter methylation is associated with favorable outcome in glioblastoma. The aim of this study was to determine whether the absolute number of methylated Cytosine-Guanine-dinucleotide-(CpG-)sites within the DMR-2 island of the MGMT-promoter may correlate with outcome in a qualitative or quant...

Descripción completa

Detalles Bibliográficos
Autores principales: Siller, Sebastian, Lauseker, Michael, Karschnia, Philipp, Niyazi, Maximilian, Eigenbrod, Sabina, Giese, Armin, Tonn, Joerg-Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934240/
https://www.ncbi.nlm.nih.gov/pubmed/33663593
http://dx.doi.org/10.1186/s40478-021-01134-5

Ejemplares similares

Ejemplares similares