Cargando…

Inhibition of BCL11B induces downregulation of PTK7 and results in growth retardation and apoptosis in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive subtype of leukemia with poor prognosis, and biomarkers and novel therapeutic targets are urgently needed for this disease. Our previous studies have found that inhibition of the B-cell leukemia/lymphoma 11B (BCL11B) gene could significant...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Kehan, Chen, Cunte, Gao, Rili, Yu, Xibao, Huang, Youxue, Chen, Zheng, Liu, Zhuandi, Chen, Shaohua, Luo, Gengxin, Huang, Xin, Przybylski, Grzegorz K., Li, Yangqiu, Zeng, Chengwu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Letter to the Editor
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934371/ https://www.ncbi.nlm.nih.gov/pubmed/33663588 http://dx.doi.org/10.1186/s40364-021-00270-3

Ejemplares similares

NRF2 activation induced by PML‐RARα promotes microRNA 125b‐1 expression and confers resistance to chemotherapy in acute promyelocytic leukemia
por: Yu, Xibao, et al.
Publicado: (2021)

BET bromodomain inhibition rescues PD-1-mediated T-cell exhaustion in acute myeloid leukemia
por: Zhong, Mengjun, et al.
Publicado: (2022)

Correction to: BET bromodomain inhibition rescues PD-1-mediated T-cell exhaustion in acute myeloid leukemia
por: Zhong, Mengjun, et al.
Publicado: (2022)

BCL11B Mutations Are Associated with Higher CD8+ T-Cell Percentage and Favorable Clinical Outcomes in Patients with T-Cell Acute Lymphoblastic Leukemia
por: Chen, Cunte, et al.
Publicado: (2023)

High expression of TMEM244 is associated with poor overall survival of patients with T-cell lymphoma
por: Chen, Cunte, et al.
Publicado: (2022)

High expression of LOC541471, GDAP1, SOD1, and STK25 is associated with poor overall survival of patients with acute myeloid leukemia
por: Yu, Xibao, et al.
Publicado: (2023)

TNFAIP3 mutation is an independent poor overall survival factor for patients with T‐cell acute lymphoblastic leukemia
por: Chen, Cunte, et al.
Publicado: (2022)

Current insight into the regulation of PD-L1 in cancer
por: Liu, Zhuandi, et al.
Publicado: (2022)

Transcriptome-Based Co-Expression of BRD4 and PD-1/PD-L1 Predicts Poor Overall Survival in Patients With Acute Myeloid Leukemia
por: Chen, Cunte, et al.
Publicado: (2021)

The importance of genomic predictors for clinical outcome of hematological malignancies
por: Chen, Cunte, et al.
Publicado: (2021)

TNFAIP3 mutation may be associated with favorable overall survival for patients with T-cell lymphoma
por: Chen, Cunte, et al.
Publicado: (2021)

Disulfiram, an aldehyde dehydrogenase inhibitor, works as a potent drug against sepsis and cancer via NETosis, pyroptosis, apoptosis, ferroptosis, and cuproptosis
por: Nie, Dingrui, et al.
Publicado: (2022)

Low Expression of CD5 and CD6 Is Associated with Poor Overall Survival for Patients with T-Cell Malignancies
por: Sui, Songnan, et al.
Publicado: (2022)

Overexpression of the long non-coding RNA PVT1 is correlated with leukemic cell proliferation in acute promyelocytic leukemia
por: Zeng, Chengwu, et al.
Publicado: (2015)

The c-Myc-regulated lncRNA NEAT1 and paraspeckles modulate imatinib-induced apoptosis in CML cells
por: Zeng, Chengwu, et al.
Publicado: (2018)

Gene expression profiles in BCL11B-siRNA treated malignant T cells
por: Huang, Xin, et al.
Publicado: (2011)

Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia
por: Huang, Xin, et al.
Publicado: (2010)

Expression patterns of immune checkpoints in acute myeloid leukemia
por: Chen, Cunte, et al.
Publicado: (2020)

Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells
por: Zeng, Chengwu, et al.
Publicado: (2014)

Age-Related Immune Profile of the T Cell Receptor Repertoire, Thymic Recent Output Function, and miRNAs
por: Xu, Yan, et al.
Publicado: (2020)

Characteristics of CARMA1-BCL10-MALT1-A20-NF-κB expression in T cell-acute lymphocytic leukemia
por: Ma, Yu, et al.
Publicado: (2014)

Persistent donor derived Vδ4 T cell clones may improve survival for recurrent T cell acute lymphoblastic leukemia after HSCT and DLI
por: Xu, Ling, et al.
Publicado: (2016)

Overexpression of MALT1-A20-NF-κB in adult B-cell acute lymphoblastic leukemia
por: Xu, Yi, et al.
Publicado: (2015)

Lower BCL11B expression is associated with adverse clinical outcome for patients with myelodysplastic syndrome
por: Huang, Xin, et al.
Publicado: (2021)

Altered expression pattern of miR-29a, miR-29b and the target genes in myeloid leukemia
por: Xu, Ling, et al.
Publicado: (2014)

Generation of Inducible BCL11B Knockout in TAL1/LMO1 Transgenic Mouse T Cell Leukemia/Lymphoma Model
por: Przybylski, Grzegorz K., et al.
Publicado: (2022)

Higher TOX Genes Expression Is Associated With Poor Overall Survival for Patients With Acute Myeloid Leukemia
por: Liang, Chaofeng, et al.
Publicado: (2021)

The role of BCL11B in hematological malignancy
por: Huang, Xin, et al.
Publicado: (2012)

Increased TOX expression associates with exhausted T cells in patients with multiple myeloma
por: Zhao, Yujie, et al.
Publicado: (2022)

Mutations increased overexpression of Notch1 in T-cell acute lymphoblastic leukemia
por: Lin, Chunlan, et al.
Publicado: (2012)

High Co-Expression of PDCD1/TIGIT/CD47/KIR3DL2 in Bone Marrow Is Associated with Poor Prognosis for Patients with Myelodysplastic Syndrome
por: Zhong, Mengjun, et al.
Publicado: (2023)

Anti-PTK7 Monoclonal Antibodies Inhibit Angiogenesis by Suppressing PTK7 Function
por: Oh, Si Won, et al.
Publicado: (2022)

Kinetochore microtubules in PTK cells
Publicado: (1992)

Repeated phototherapeutic keratectomy (PTK) followed by PTK with photorefractive keratectomy for anterior granular corneal dystrophy
por: Sridhar, Uma, et al.
Publicado: (2020)

Decreased level of recent thymic emigrants in CD4+ and CD8+T cells from CML patients
por: Li, Yangqiu, et al.
Publicado: (2010)

Alteration of gene expression profile in CD3(+) T-cells after downregulating MALT1
por: Wang, Xu, et al.
Publicado: (2018)

Tumor mutation burden estimated by a 69-gene-panel is associated with overall survival in patients with diffuse large B-cell lymphoma
por: Chen, Cunte, et al.
Publicado: (2021)

Roles of METTL3 in cancer: mechanisms and therapeutic targeting
por: Zeng, Chengwu, et al.
Publicado: (2020)

Interpolar spindle microtubules in PTK cells
Publicado: (1993)

A polymethoxyflavone from Laggera pterodonta induces apoptosis in imatinib-resistant K562R cells via activation of the intrinsic apoptosis pathway
por: Cao, Changshu, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_rhh5rp46ag3gg3i0uen8fatqok