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The impact of subclinical hypothyroidism on long-term outcomes in older patients undergoing percutaneous coronary intervention
BACKGROUND: Subclinical hypothyroidism (SCH) is reportedly associated with an increased risk of adverse events in patients undergoing percutaneous coronary intervention (PCI). The prognostic significance of SCH in the elderly was poorly defined. The purpose of this study was to evaluate the associat...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934482/ https://www.ncbi.nlm.nih.gov/pubmed/33673843 http://dx.doi.org/10.1186/s12902-021-00702-z |
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author | Liu, Yong-Sheng Wei, Mei Wang, Le Liu, Gang Ma, Guo-Ping Ono, Katsushige Cao, Ze-Long Yang, Man Zheng, Ming-Qi |
author_facet | Liu, Yong-Sheng Wei, Mei Wang, Le Liu, Gang Ma, Guo-Ping Ono, Katsushige Cao, Ze-Long Yang, Man Zheng, Ming-Qi |
author_sort | Liu, Yong-Sheng |
collection | PubMed |
description | BACKGROUND: Subclinical hypothyroidism (SCH) is reportedly associated with an increased risk of adverse events in patients undergoing percutaneous coronary intervention (PCI). The prognostic significance of SCH in the elderly was poorly defined. The purpose of this study was to evaluate the association between SCH and long-term outcomes in older patients undergoing PCI. METHODS: Three thousand one hundred sixty-eight patients aged 65 years or older who underwent PCI from January 2012 to October 2014 were included. Patients were divided into SCH group (n = 320) and euthyroidism (ET) group (n = 2848) based on thyroid function test. Cox proportional hazard regression analyses were used to estimate the relative risks (RRs) of all-cause death and cardiac death for patients with SCH during a 4-year follow-up period. RESULTS: There were 227 deaths during the follow-up period including 124 deaths caused by cardiac events. There was no significant difference in mortality rate between the SCH group and the ET group (p > 0.05). After adjustment for covariates, compared with patients with ET, the RRs of death from all-cause and cardiac in patients with SCH were 1.261 (95%CI: 0.802–1.982, p = 0.315) and 1.231 (95%CI: 0.650–2.334, p = 0.524), respectively. When SCH was stratified by age, gender, and degree of thyroid-stimulating hormone elevation, no significant associations were also found in any stratum. CONCLUSION: Our investigation revealed that SCH was negatively associated with the outcome of PCI in older patients. |
format | Online Article Text |
id | pubmed-7934482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-79344822021-03-08 The impact of subclinical hypothyroidism on long-term outcomes in older patients undergoing percutaneous coronary intervention Liu, Yong-Sheng Wei, Mei Wang, Le Liu, Gang Ma, Guo-Ping Ono, Katsushige Cao, Ze-Long Yang, Man Zheng, Ming-Qi BMC Endocr Disord Research Article BACKGROUND: Subclinical hypothyroidism (SCH) is reportedly associated with an increased risk of adverse events in patients undergoing percutaneous coronary intervention (PCI). The prognostic significance of SCH in the elderly was poorly defined. The purpose of this study was to evaluate the association between SCH and long-term outcomes in older patients undergoing PCI. METHODS: Three thousand one hundred sixty-eight patients aged 65 years or older who underwent PCI from January 2012 to October 2014 were included. Patients were divided into SCH group (n = 320) and euthyroidism (ET) group (n = 2848) based on thyroid function test. Cox proportional hazard regression analyses were used to estimate the relative risks (RRs) of all-cause death and cardiac death for patients with SCH during a 4-year follow-up period. RESULTS: There were 227 deaths during the follow-up period including 124 deaths caused by cardiac events. There was no significant difference in mortality rate between the SCH group and the ET group (p > 0.05). After adjustment for covariates, compared with patients with ET, the RRs of death from all-cause and cardiac in patients with SCH were 1.261 (95%CI: 0.802–1.982, p = 0.315) and 1.231 (95%CI: 0.650–2.334, p = 0.524), respectively. When SCH was stratified by age, gender, and degree of thyroid-stimulating hormone elevation, no significant associations were also found in any stratum. CONCLUSION: Our investigation revealed that SCH was negatively associated with the outcome of PCI in older patients. BioMed Central 2021-03-05 /pmc/articles/PMC7934482/ /pubmed/33673843 http://dx.doi.org/10.1186/s12902-021-00702-z Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Liu, Yong-Sheng Wei, Mei Wang, Le Liu, Gang Ma, Guo-Ping Ono, Katsushige Cao, Ze-Long Yang, Man Zheng, Ming-Qi The impact of subclinical hypothyroidism on long-term outcomes in older patients undergoing percutaneous coronary intervention |
title | The impact of subclinical hypothyroidism on long-term outcomes in older patients undergoing percutaneous coronary intervention |
title_full | The impact of subclinical hypothyroidism on long-term outcomes in older patients undergoing percutaneous coronary intervention |
title_fullStr | The impact of subclinical hypothyroidism on long-term outcomes in older patients undergoing percutaneous coronary intervention |
title_full_unstemmed | The impact of subclinical hypothyroidism on long-term outcomes in older patients undergoing percutaneous coronary intervention |
title_short | The impact of subclinical hypothyroidism on long-term outcomes in older patients undergoing percutaneous coronary intervention |
title_sort | impact of subclinical hypothyroidism on long-term outcomes in older patients undergoing percutaneous coronary intervention |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934482/ https://www.ncbi.nlm.nih.gov/pubmed/33673843 http://dx.doi.org/10.1186/s12902-021-00702-z |
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