Diversity roles of CHD1L in normal cell function and tumorigenesis

Chromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) is a multifunctional protein participated in diverse cellular processes, including chromosome remodeling, cell differentiation and development. CHD1L is a regulator of chromosomal integrity maintenance, DNA repair and transcription...

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Autores principales: Xiong, Xifeng, Lai, Xudong, Li, Aiguo, Liu, Zhihe, Ma, Ningfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934534/
https://www.ncbi.nlm.nih.gov/pubmed/33663617
http://dx.doi.org/10.1186/s40364-021-00269-w
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author Xiong, Xifeng
Lai, Xudong
Li, Aiguo
Liu, Zhihe
Ma, Ningfang
author_facet Xiong, Xifeng
Lai, Xudong
Li, Aiguo
Liu, Zhihe
Ma, Ningfang
author_sort Xiong, Xifeng
collection PubMed
description Chromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) is a multifunctional protein participated in diverse cellular processes, including chromosome remodeling, cell differentiation and development. CHD1L is a regulator of chromosomal integrity maintenance, DNA repair and transcriptional regulation through its bindings to DNA. By regulating kinds of complex networks, CHD1L has been identified as a potent anti-apoptotic and pro-proliferative factor. CHD1L is also an oncoprotein since its overexpression leads to dysregulation of related downstream targets in various cancers. The latest advances in the functional molecular basis of CHD1L in normal cells will be described in this review. As the same time, we will describe the current understanding of CHD1L in terms of structure, characteristics, function and the molecular mechanisms underlying CHD1L in tumorigenesis. We inference that the role of CHD1L which involve in multiple cellular processes and oncogenesis is well worth further studying in basic biology and clinical relevance.
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spelling pubmed-79345342021-03-08 Diversity roles of CHD1L in normal cell function and tumorigenesis Xiong, Xifeng Lai, Xudong Li, Aiguo Liu, Zhihe Ma, Ningfang Biomark Res Review Chromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) is a multifunctional protein participated in diverse cellular processes, including chromosome remodeling, cell differentiation and development. CHD1L is a regulator of chromosomal integrity maintenance, DNA repair and transcriptional regulation through its bindings to DNA. By regulating kinds of complex networks, CHD1L has been identified as a potent anti-apoptotic and pro-proliferative factor. CHD1L is also an oncoprotein since its overexpression leads to dysregulation of related downstream targets in various cancers. The latest advances in the functional molecular basis of CHD1L in normal cells will be described in this review. As the same time, we will describe the current understanding of CHD1L in terms of structure, characteristics, function and the molecular mechanisms underlying CHD1L in tumorigenesis. We inference that the role of CHD1L which involve in multiple cellular processes and oncogenesis is well worth further studying in basic biology and clinical relevance. BioMed Central 2021-03-04 /pmc/articles/PMC7934534/ /pubmed/33663617 http://dx.doi.org/10.1186/s40364-021-00269-w Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Xiong, Xifeng
Lai, Xudong
Li, Aiguo
Liu, Zhihe
Ma, Ningfang
Diversity roles of CHD1L in normal cell function and tumorigenesis
title Diversity roles of CHD1L in normal cell function and tumorigenesis
title_full Diversity roles of CHD1L in normal cell function and tumorigenesis
title_fullStr Diversity roles of CHD1L in normal cell function and tumorigenesis
title_full_unstemmed Diversity roles of CHD1L in normal cell function and tumorigenesis
title_short Diversity roles of CHD1L in normal cell function and tumorigenesis
title_sort diversity roles of chd1l in normal cell function and tumorigenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934534/
https://www.ncbi.nlm.nih.gov/pubmed/33663617
http://dx.doi.org/10.1186/s40364-021-00269-w
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