Cargando…
Predictors of treatment failure during the first year in newly diagnosed type 2 diabetes patients: a retrospective, observational study
BACKGROUND: Diabetes patients who fail to achieve early glycemic control may increase the future risk of complications and mortality. The aim of the study was to identify factors that predict treatment failure (TF) during the first year in adults with newly diagnosed type 2 diabetes mellitus (T2DM)....
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934644/ https://www.ncbi.nlm.nih.gov/pubmed/33717708 http://dx.doi.org/10.7717/peerj.11005 |
_version_ | 1783660853901393920 |
---|---|
author | Sia, Hon-Ke Kor, Chew-Teng Tu, Shih-Te Liao, Pei-Yung Chang, Yu-Chia |
author_facet | Sia, Hon-Ke Kor, Chew-Teng Tu, Shih-Te Liao, Pei-Yung Chang, Yu-Chia |
author_sort | Sia, Hon-Ke |
collection | PubMed |
description | BACKGROUND: Diabetes patients who fail to achieve early glycemic control may increase the future risk of complications and mortality. The aim of the study was to identify factors that predict treatment failure (TF) during the first year in adults with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS: This retrospective cohort study conducted at a medical center in Taiwan enrolled 4,282 eligible patients with newly diagnosed T2DM between 2002 and 2017. Data were collected from electronic medical records. TF was defined as the HbA1c value >7% at the end of 1-year observation. A subgroup analysis of 2,392 patients with baseline HbA1c ≥8% was performed. Multivariable logistic regression analysis using backward elimination was applied to establish prediction models. RESULTS: Of all study participants, 1,439 (33.6%) were classified as TF during the first year. For every 1% increase in baseline HbA1c, the risk of TF was 1.17 (95% CI 1.15–1.20) times higher. Patients with baseline HbA1c ≥8% had a higher rate of TF than those with HbA1c <8% (42.0 vs 23.0%, p < 0.001). Medication adherence, self-monitoring of blood glucose (SMBG), regular exercise, gender (men), non-insulin treatment, and enrollment during 2010–2017 predicted a significant lower risk of TF in both of the primary and subgroup models. CONCLUSIONS: Newly diagnosed diabetes patients with baseline HbA1c ≥8% did have a much higher rate of TF during the first year. Subgroup analysis for them highlights the important predictors of TF, including medication adherence, performing SMBG, regular exercise, and gender, in achieving glycemic control. |
format | Online Article Text |
id | pubmed-7934644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79346442021-03-11 Predictors of treatment failure during the first year in newly diagnosed type 2 diabetes patients: a retrospective, observational study Sia, Hon-Ke Kor, Chew-Teng Tu, Shih-Te Liao, Pei-Yung Chang, Yu-Chia PeerJ Diabetes and Endocrinology BACKGROUND: Diabetes patients who fail to achieve early glycemic control may increase the future risk of complications and mortality. The aim of the study was to identify factors that predict treatment failure (TF) during the first year in adults with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS: This retrospective cohort study conducted at a medical center in Taiwan enrolled 4,282 eligible patients with newly diagnosed T2DM between 2002 and 2017. Data were collected from electronic medical records. TF was defined as the HbA1c value >7% at the end of 1-year observation. A subgroup analysis of 2,392 patients with baseline HbA1c ≥8% was performed. Multivariable logistic regression analysis using backward elimination was applied to establish prediction models. RESULTS: Of all study participants, 1,439 (33.6%) were classified as TF during the first year. For every 1% increase in baseline HbA1c, the risk of TF was 1.17 (95% CI 1.15–1.20) times higher. Patients with baseline HbA1c ≥8% had a higher rate of TF than those with HbA1c <8% (42.0 vs 23.0%, p < 0.001). Medication adherence, self-monitoring of blood glucose (SMBG), regular exercise, gender (men), non-insulin treatment, and enrollment during 2010–2017 predicted a significant lower risk of TF in both of the primary and subgroup models. CONCLUSIONS: Newly diagnosed diabetes patients with baseline HbA1c ≥8% did have a much higher rate of TF during the first year. Subgroup analysis for them highlights the important predictors of TF, including medication adherence, performing SMBG, regular exercise, and gender, in achieving glycemic control. PeerJ Inc. 2021-03-02 /pmc/articles/PMC7934644/ /pubmed/33717708 http://dx.doi.org/10.7717/peerj.11005 Text en ©2021 Sia et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Diabetes and Endocrinology Sia, Hon-Ke Kor, Chew-Teng Tu, Shih-Te Liao, Pei-Yung Chang, Yu-Chia Predictors of treatment failure during the first year in newly diagnosed type 2 diabetes patients: a retrospective, observational study |
title | Predictors of treatment failure during the first year in newly diagnosed type 2 diabetes patients: a retrospective, observational study |
title_full | Predictors of treatment failure during the first year in newly diagnosed type 2 diabetes patients: a retrospective, observational study |
title_fullStr | Predictors of treatment failure during the first year in newly diagnosed type 2 diabetes patients: a retrospective, observational study |
title_full_unstemmed | Predictors of treatment failure during the first year in newly diagnosed type 2 diabetes patients: a retrospective, observational study |
title_short | Predictors of treatment failure during the first year in newly diagnosed type 2 diabetes patients: a retrospective, observational study |
title_sort | predictors of treatment failure during the first year in newly diagnosed type 2 diabetes patients: a retrospective, observational study |
topic | Diabetes and Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934644/ https://www.ncbi.nlm.nih.gov/pubmed/33717708 http://dx.doi.org/10.7717/peerj.11005 |
work_keys_str_mv | AT siahonke predictorsoftreatmentfailureduringthefirstyearinnewlydiagnosedtype2diabetespatientsaretrospectiveobservationalstudy AT korchewteng predictorsoftreatmentfailureduringthefirstyearinnewlydiagnosedtype2diabetespatientsaretrospectiveobservationalstudy AT tushihte predictorsoftreatmentfailureduringthefirstyearinnewlydiagnosedtype2diabetespatientsaretrospectiveobservationalstudy AT liaopeiyung predictorsoftreatmentfailureduringthefirstyearinnewlydiagnosedtype2diabetespatientsaretrospectiveobservationalstudy AT changyuchia predictorsoftreatmentfailureduringthefirstyearinnewlydiagnosedtype2diabetespatientsaretrospectiveobservationalstudy |