Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs

• Following the announcement on December 2020 about the emergence of a new variant (VOC 202012/01, B.1.1.7 lineage) in the United Kingdom, a targeted surveillance was put in place in the Abruzzo region (Italy), which allowed detection of 313 persons affected by lineage B.1.1.7, up to the 20th of Feb...

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Detalles Bibliográficos
Autores principales: Calistri, Paolo, Amato, Laura, Puglia, Ilaria, Cito, Francesca, Di Giuseppe, Alessandra, Danzetta, Maria Luisa, Morelli, Daniela, Di Domenico, Marco, Caporale, Marialuigia, Scialabba, Silvia, Portanti, Ottavio, Curini, Valentina, Perletta, Fabrizia, Cammà, Cesare, Ancora, Massimo, Savini, Giovanni, Migliorati, Giacomo, D’Alterio, Nicola, Lorusso, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934691/
https://www.ncbi.nlm.nih.gov/pubmed/33684558
http://dx.doi.org/10.1016/j.ijid.2021.03.005
Descripción
Sumario:• Following the announcement on December 2020 about the emergence of a new variant (VOC 202012/01, B.1.1.7 lineage) in the United Kingdom, a targeted surveillance was put in place in the Abruzzo region (Italy), which allowed detection of 313 persons affected by lineage B.1.1.7, up to the 20th of February 2021. We investigated the results of RT-PCR on nasopharyngeal swabs tested from December 2020 to February 2021 to verify any difference on the viral load and persistence between people infected by lineage B.1.1.7 and others. Statistically significant lower values of C(T) associated with the detection of the N protein encoding gene (C(T) N) were observed in persons with lineage B.1.1.7 infection (median C(T) N = 15.8) in comparison to those infected by other lineages (median C(T) N = 16.9). A significantly longer duration of the persistence of SARS-CoV-2 RNA in nasopharyngeal swabs was observed in persons with lineage B.1.1.7 infection (16 days) in comparison to those infected by other lineages (14 days).

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