Menthyl esterification allows chiral resolution for the synthesis of artificial glutamate analogs

Herein, we report the enantiospecific synthesis of two artificial glutamate analogs designed based on IKM-159, an antagonist selective to the AMPA-type ionotropic glutamate receptor. The synthesis features the chiral resolution of the carboxylic acid intermediate by the esterification with ʟ-menthol...

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Detalles Bibliográficos
Autores principales: Morokuma, Kenji, Tsukamoto, Shuntaro, Mori, Kyosuke, Miyako, Kei, Sakai, Ryuichi, Irie, Raku, Oikawa, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934734/
https://www.ncbi.nlm.nih.gov/pubmed/33727977
http://dx.doi.org/10.3762/bjoc.17.48

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934734/
https://www.ncbi.nlm.nih.gov/pubmed/33727977
http://dx.doi.org/10.3762/bjoc.17.48

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