Metal-free visible-light-enabled vicinal trifluoromethyl dithiolation of unactivated alkenes

The difunctionalization of alkenes involving a trifluoromethylthio group (SCF(3)) for the conversion of versatile and readily available olefins into structurally more complex molecules has been successfully studied. However, the disproportionate dithiolation of alkenes is unknown. Herein, a transiti...

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Detalles Bibliográficos
Autores principales: Li, Xiaojuan, Zhang, Qiang, Zhang, Weigang, Ma, Jinzhu, Wang, Yi, Pan, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934782/
https://www.ncbi.nlm.nih.gov/pubmed/33727978
http://dx.doi.org/10.3762/bjoc.17.49
Descripción
Sumario:The difunctionalization of alkenes involving a trifluoromethylthio group (SCF(3)) for the conversion of versatile and readily available olefins into structurally more complex molecules has been successfully studied. However, the disproportionate dithiolation of alkenes is unknown. Herein, a transition-metal-free protocol is presented for the vicinal trifluoromethylthio–thiolation of unactivated alkenes via a radical process under mild conditions with a broad substrate scope and excellent tolerance.

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