Metal-free visible-light-enabled vicinal trifluoromethyl dithiolation of unactivated alkenes

The difunctionalization of alkenes involving a trifluoromethylthio group (SCF(3)) for the conversion of versatile and readily available olefins into structurally more complex molecules has been successfully studied. However, the disproportionate dithiolation of alkenes is unknown. Herein, a transiti...

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Detalles Bibliográficos
Autores principales: Li, Xiaojuan, Zhang, Qiang, Zhang, Weigang, Ma, Jinzhu, Wang, Yi, Pan, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934782/
https://www.ncbi.nlm.nih.gov/pubmed/33727978
http://dx.doi.org/10.3762/bjoc.17.49
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author Li, Xiaojuan
Zhang, Qiang
Zhang, Weigang
Ma, Jinzhu
Wang, Yi
Pan, Yi
author_facet Li, Xiaojuan
Zhang, Qiang
Zhang, Weigang
Ma, Jinzhu
Wang, Yi
Pan, Yi
author_sort Li, Xiaojuan
collection PubMed
description The difunctionalization of alkenes involving a trifluoromethylthio group (SCF(3)) for the conversion of versatile and readily available olefins into structurally more complex molecules has been successfully studied. However, the disproportionate dithiolation of alkenes is unknown. Herein, a transition-metal-free protocol is presented for the vicinal trifluoromethylthio–thiolation of unactivated alkenes via a radical process under mild conditions with a broad substrate scope and excellent tolerance.
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spelling pubmed-79347822021-03-15 Metal-free visible-light-enabled vicinal trifluoromethyl dithiolation of unactivated alkenes Li, Xiaojuan Zhang, Qiang Zhang, Weigang Ma, Jinzhu Wang, Yi Pan, Yi Beilstein J Org Chem Full Research Paper The difunctionalization of alkenes involving a trifluoromethylthio group (SCF(3)) for the conversion of versatile and readily available olefins into structurally more complex molecules has been successfully studied. However, the disproportionate dithiolation of alkenes is unknown. Herein, a transition-metal-free protocol is presented for the vicinal trifluoromethylthio–thiolation of unactivated alkenes via a radical process under mild conditions with a broad substrate scope and excellent tolerance. Beilstein-Institut 2021-02-24 /pmc/articles/PMC7934782/ /pubmed/33727978 http://dx.doi.org/10.3762/bjoc.17.49 Text en Copyright © 2021, Li et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/terms/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the author(s) and source are credited and that individual graphics may be subject to special legal provisions. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms/terms)
spellingShingle Full Research Paper
Li, Xiaojuan
Zhang, Qiang
Zhang, Weigang
Ma, Jinzhu
Wang, Yi
Pan, Yi
Metal-free visible-light-enabled vicinal trifluoromethyl dithiolation of unactivated alkenes
title Metal-free visible-light-enabled vicinal trifluoromethyl dithiolation of unactivated alkenes
title_full Metal-free visible-light-enabled vicinal trifluoromethyl dithiolation of unactivated alkenes
title_fullStr Metal-free visible-light-enabled vicinal trifluoromethyl dithiolation of unactivated alkenes
title_full_unstemmed Metal-free visible-light-enabled vicinal trifluoromethyl dithiolation of unactivated alkenes
title_short Metal-free visible-light-enabled vicinal trifluoromethyl dithiolation of unactivated alkenes
title_sort metal-free visible-light-enabled vicinal trifluoromethyl dithiolation of unactivated alkenes
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934782/
https://www.ncbi.nlm.nih.gov/pubmed/33727978
http://dx.doi.org/10.3762/bjoc.17.49
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