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Amino- and polyaminophthalazin-1(2H)-ones: synthesis, coordination properties, and biological activity
Amino- and polyaminophthalazinones were synthesized by the palladium‐catalyzed amination (alkyl- and arylamines, polyamines) of 4-bromophthalazinones in good yields. The coordinating properties of selected aminophthalazinones towards Cu(II) ions were investigated and the participation of the nitroge...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Beilstein-Institut
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934800/ https://www.ncbi.nlm.nih.gov/pubmed/33727979 http://dx.doi.org/10.3762/bjoc.17.50 |
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author | Malinowski, Zbigniew Fornal, Emilia Sumara, Agata Kontek, Renata Bukowski, Karol Pasternak, Beata Sroczyński, Dariusz Kusz, Joachim Małecka, Magdalena Nowak, Monika |
author_facet | Malinowski, Zbigniew Fornal, Emilia Sumara, Agata Kontek, Renata Bukowski, Karol Pasternak, Beata Sroczyński, Dariusz Kusz, Joachim Małecka, Magdalena Nowak, Monika |
author_sort | Malinowski, Zbigniew |
collection | PubMed |
description | Amino- and polyaminophthalazinones were synthesized by the palladium‐catalyzed amination (alkyl- and arylamines, polyamines) of 4-bromophthalazinones in good yields. The coordinating properties of selected aminophthalazinones towards Cu(II) ions were investigated and the participation of the nitrogen atoms in the complexation of the metal ion was shown. A biological screening of the potential cytotoxicity of selected synthesized compounds on HT-29 and PC-3 cell lines, as well as on the L-929 cell line, proved that some amino derivatives of phthalazinone show interesting anticancer activities. The detailed synthesis, spectroscopic data, and biological assays are reported. |
format | Online Article Text |
id | pubmed-7934800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-79348002021-03-15 Amino- and polyaminophthalazin-1(2H)-ones: synthesis, coordination properties, and biological activity Malinowski, Zbigniew Fornal, Emilia Sumara, Agata Kontek, Renata Bukowski, Karol Pasternak, Beata Sroczyński, Dariusz Kusz, Joachim Małecka, Magdalena Nowak, Monika Beilstein J Org Chem Full Research Paper Amino- and polyaminophthalazinones were synthesized by the palladium‐catalyzed amination (alkyl- and arylamines, polyamines) of 4-bromophthalazinones in good yields. The coordinating properties of selected aminophthalazinones towards Cu(II) ions were investigated and the participation of the nitrogen atoms in the complexation of the metal ion was shown. A biological screening of the potential cytotoxicity of selected synthesized compounds on HT-29 and PC-3 cell lines, as well as on the L-929 cell line, proved that some amino derivatives of phthalazinone show interesting anticancer activities. The detailed synthesis, spectroscopic data, and biological assays are reported. Beilstein-Institut 2021-02-25 /pmc/articles/PMC7934800/ /pubmed/33727979 http://dx.doi.org/10.3762/bjoc.17.50 Text en Copyright © 2021, Malinowski et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/terms/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the author(s) and source are credited and that individual graphics may be subject to special legal provisions. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms/terms) |
spellingShingle | Full Research Paper Malinowski, Zbigniew Fornal, Emilia Sumara, Agata Kontek, Renata Bukowski, Karol Pasternak, Beata Sroczyński, Dariusz Kusz, Joachim Małecka, Magdalena Nowak, Monika Amino- and polyaminophthalazin-1(2H)-ones: synthesis, coordination properties, and biological activity |
title | Amino- and polyaminophthalazin-1(2H)-ones: synthesis, coordination properties, and biological activity |
title_full | Amino- and polyaminophthalazin-1(2H)-ones: synthesis, coordination properties, and biological activity |
title_fullStr | Amino- and polyaminophthalazin-1(2H)-ones: synthesis, coordination properties, and biological activity |
title_full_unstemmed | Amino- and polyaminophthalazin-1(2H)-ones: synthesis, coordination properties, and biological activity |
title_short | Amino- and polyaminophthalazin-1(2H)-ones: synthesis, coordination properties, and biological activity |
title_sort | amino- and polyaminophthalazin-1(2h)-ones: synthesis, coordination properties, and biological activity |
topic | Full Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934800/ https://www.ncbi.nlm.nih.gov/pubmed/33727979 http://dx.doi.org/10.3762/bjoc.17.50 |
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