Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2–induced systemic toxicity

Extrapulmonary manifestations of COVID-19 are associated with a much higher mortality rate than pulmonary manifestations. However, little is known about the pathogenesis of systemic complications of COVID-19. Here, we create a murine model of SARS-CoV-2–induced severe systemic toxicity and multiorga...

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Detalles Bibliográficos
Autores principales: Li, Shen, Ma, Feiyang, Yokota, Tomohiro, Garcia, Gustavo, Palermo, Amelia, Wang, Yijie, Farrell, Colin, Wang, Yu-Chen, Wu, Rimao, Zhou, Zhiqiang, Pan, Calvin, Morselli, Marco, Teitell, Michael A., Ryazantsev, Sergey, Fishbein, Gregory A., Hoeve, Johanna ten, Arboleda, Valerie A., Bloom, Joshua, Dillon, Barbara, Pellegrini, Matteo, Lusis, Aldons J., Graeber, Thomas G., Arumugaswami, Vaithilingaraja, Deb, Arjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934846/
https://www.ncbi.nlm.nih.gov/pubmed/33284134
http://dx.doi.org/10.1172/jci.insight.145027

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