Identification of Wee1 as a target in combination with avapritinib for gastrointestinal stromal tumor treatment

Management of gastrointestinal stromal tumors (GISTs) has been revolutionized by the identification of activating mutations in KIT and PDGFRA and clinical application of RTK inhibitors in advanced disease. Stratification of GISTs into molecularly defined subsets provides insight into clinical behavi...

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Detalles Bibliográficos
Autores principales: Ye, Shuai, Sharipova, Dinara, Kozinova, Marya, Klug, Lilli, D’Souza, Jimson, Belinsky, Martin G., Johnson, Katherine J., Einarson, Margret B., Devarajan, Karthik, Zhou, Yan, Litwin, Samuel, Heinrich, Michael C., DeMatteo, Ronald, von Mehren, Margaret, Duncan, James S., Rink, Lori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934848/
https://www.ncbi.nlm.nih.gov/pubmed/33320833
http://dx.doi.org/10.1172/jci.insight.143474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934848/
https://www.ncbi.nlm.nih.gov/pubmed/33320833
http://dx.doi.org/10.1172/jci.insight.143474

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