The longevity gene mIndy (I’m Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms

Reduced expression of the plasma membrane citrate transporter INDY (acronym I’m Not Dead, Yet) extends life span in lower organisms. Deletion of the mammalian Indy (mIndy) gene in rodents improves metabolism via mechanisms akin to caloric restriction, known to lower blood pressure (BP) by sympathoad...

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Detalles Bibliográficos
Autores principales: Willmes, Diana M., Daniels, Martin, Kurzbach, Anica, Lieske, Stefanie, Bechmann, Nicole, Schumann, Tina, Henke, Christine, El-Agroudy, Nermeen N., Da Costa Goncalves, Andrey C., Peitzsch, Mirko, Hofmann, Anja, Kanczkowski, Waldemar, Kräker, Kristin, Müller, Dominik N., Morawietz, Henning, Deussen, Andreas, Wagner, Michael, El-Armouche, Ali, Helfand, Stephen L., Bornstein, Stephan R., de Cabo, Rafael, Bernier, Michel, Eisenhofer, Graeme, Tank, Jens, Jordan, Jens, Birkenfeld, Andreas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934862/
https://www.ncbi.nlm.nih.gov/pubmed/33491666
http://dx.doi.org/10.1172/jci.insight.136083

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