Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML

The cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation. Recurrent somatic mutations in the cohesin complex are frequent genetic drivers in cancer, including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Here, using genetic dependency...

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Detalles Bibliográficos
Autores principales: Tothova, Zuzana, Valton, Anne-Laure, Gorelov, Rebecca A., Vallurupalli, Mounica, Krill-Burger, John M., Holmes, Amie, Landers, Catherine C., Haydu, J. Erika, Malolepsza, Edyta, Hartigan, Christina, Donahue, Melanie, Popova, Katerina D., Koochaki, Sebastian, Venev, Sergey V., Rivera, Jeanne, Chen, Edwin, Lage, Kasper, Schenone, Monica, D’Andrea, Alan D., Carr, Steven A., Morgan, Elizabeth A., Dekker, Job, Ebert, Benjamin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934867/
https://www.ncbi.nlm.nih.gov/pubmed/33351783
http://dx.doi.org/10.1172/jci.insight.142149

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