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Exhausted-like CD8(+) T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects

Clinical trials of biologic therapies in type 1 diabetes (T1D) aim to mitigate autoimmune destruction of pancreatic β cells through immune perturbation and serve as resources to elucidate immunological mechanisms in health and disease. In the T1DAL trial of alefacept (LFA3-Ig) in recent-onset T1D, e...

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Detalles Bibliográficos
Autores principales:	Diggins, Kirsten E., Serti, Elisavet, Muir, Virginia, Rosasco, Mario, Lu, TingTing, Balmas, Elisa, Nepom, Gerald, Long, S. Alice, Linsley, Peter S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934874/ https://www.ncbi.nlm.nih.gov/pubmed/33351781 http://dx.doi.org/10.1172/jci.insight.142680

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