TCF-1 regulates HIV-specific CD8(+) T cell expansion capacity

Although many HIV cure strategies seek to expand HIV-specific CD8(+) T cells to control the virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory properties (i.e., the ability to proliferate and generate secondary effector cells) is a key feature of exhaus...

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Detalles Bibliográficos
Autores principales: Rutishauser, Rachel L., Deguit, Christian Deo T., Hiatt, Joseph, Blaeschke, Franziska, Roth, Theodore L., Wang, Lynn, Raymond, Kyle A., Starke, Carly E., Mudd, Joseph C., Chen, Wenxuan, Smullin, Carolyn, Matus-Nicodemos, Rodrigo, Hoh, Rebecca, Krone, Melissa, Hecht, Frederick M., Pilcher, Christopher D., Martin, Jeffrey N., Koup, Richard A., Douek, Daniel C., Brenchley, Jason M., Sékaly, Rafick-Pierre, Pillai, Satish K., Marson, Alexander, Deeks, Steven G., McCune, Joseph M., Hunt, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934879/
https://www.ncbi.nlm.nih.gov/pubmed/33351785
http://dx.doi.org/10.1172/jci.insight.136648

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