Early brainstem ([18F])THK5351 uptake is linked to cortical hyperexcitability in healthy aging

BACKGROUND: Neuronal hyperexcitability characterizes the early stages of Alzheimer’s disease (AD). In animals, early misfolded tau and amyloid-β (Aβ) protein accumulation — both central to AD neuropathology — promote cortical excitability and neuronal network dysfunction. In healthy humans, misfolde...

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Detalles Bibliográficos
Autores principales: Van Egroo, Maxime, Chylinski, Daphne, Narbutas, Justinas, Besson, Gabriel, Muto, Vincenzo, Schmidt, Christina, Marzoli, Davide, Cardone, Paolo, Vandeleene, Nora, Grignard, Martin, Luxen, André, Salmon, Eric, Lambert, Christian, Bastin, Christine, Collette, Fabienne, Phillips, Christophe, Maquet, Pierre, Bahri, Mohamed Ali, Balteau, Evelyne, Vandewalle, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934880/
https://www.ncbi.nlm.nih.gov/pubmed/33290274
http://dx.doi.org/10.1172/jci.insight.142514

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