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Direct conversion of osteosarcoma to adipocytes by targeting TNIK

Osteosarcoma (OS) is an aggressive mesenchymal tumor for which no molecularly targeted therapies are available. We have previously identified TRAF2- and NCK-interacting protein kinase (TNIK) as an essential factor for the transactivation of Wnt signal target genes and shown that its inhibition leads...

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Detalles Bibliográficos
Autores principales:	Hirozane, Toru, Masuda, Mari, Sugano, Teppei, Sekita, Tetsuya, Goto, Naoko, Aoyama, Toru, Sakagami, Takato, Uno, Yuko, Moriyama, Hideki, Sawa, Masaaki, Asano, Naofumi, Nakamura, Masaya, Matsumoto, Morio, Nakayama, Robert, Kondo, Tadashi, Kawai, Akira, Kobayashi, Eisuke, Yamada, Tesshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934882/ https://www.ncbi.nlm.nih.gov/pubmed/33400690 http://dx.doi.org/10.1172/jci.insight.137245

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