Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade

Limited experimental evidence bridges nutrition and cancer immunosurveillance. Here, we show that ketogenic diet (KD) — or its principal ketone body, 3-hydroxybutyrate (3HB), most specifically in intermittent scheduling — induced T cell–dependent tumor growth retardation of aggressive tumor models....

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Detalles Bibliográficos
Autores principales: Ferrere, Gladys, Tidjani Alou, Maryam, Liu, Peng, Goubet, Anne-Gaëlle, Fidelle, Marine, Kepp, Oliver, Durand, Sylvère, Iebba, Valerio, Fluckiger, Aurélie, Daillère, Romain, Thelemaque, Cassandra, Grajeda-Iglesias, Claudia, Alves Costa Silva, Carolina, Aprahamian, Fanny, Lefevre, Déborah, Zhao, Liwei, Ryffel, Bernhard, Colomba, Emeline, Arnedos, Monica, Drubay, Damien, Rauber, Conrad, Raoult, Didier, Asnicar, Francesco, Spector, Tim, Segata, Nicola, Derosa, Lisa, Kroemer, Guido, Zitvogel, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934884/
https://www.ncbi.nlm.nih.gov/pubmed/33320838
http://dx.doi.org/10.1172/jci.insight.145207

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