Cargando…

The Na(+), K(+)-ATPase β1 subunit regulates epithelial tight junctions via MRCKα

An intact lung epithelial barrier is essential for lung homeostasis. The Na(+), K(+)-ATPase (NKA), primarily serving as an ion transporter, also regulates epithelial barrier function via modulation of tight junctions. However, the underlying mechanism is not well understood. Here, we show that overe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bai, Haiqing, Zhou, Rui, Barravecchia, Michael, Norman, Rosemary, Friedman, Alan, Yu, Deborah, Lin, Xin, Young, Jennifer L., Dean, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934944/ https://www.ncbi.nlm.nih.gov/pubmed/33507884 http://dx.doi.org/10.1172/jci.insight.134881

Ejemplares similares

21-Benzylidene Digoxin: A Proapoptotic Cardenolide of Cancer Cells That Up-Regulates Na,K-ATPase and Epithelial Tight Junctions
por: Rocha, Sayonarah C., et al.
Publicado: (2014)

Tuning of the Na,K-ATPase by the beta subunit
por: Hilbers, Florian, et al.
Publicado: (2016)

Transcriptional regulators of Na,K-ATPase subunits
por: Li, Zhiqin, et al.
Publicado: (2015)

β subunit affects Na(+) and K(+) affinities of Na(+)/K(+)-ATPase: Na(+) and K(+) affinities of a hybrid Na(+)/K(+)-ATPase composed of insect α and mammalian β subunits
por: Homareda, Haruo, et al.
Publicado: (2022)

Upregulation of alveolar fluid clearance is not sufficient for Na(+),K(+)-ATPase β subunit-mediated gene therapy of LPS-induced acute lung injury in mice
por: Liu, Jing, et al.
Publicado: (2023)

Tight Coupling of Na(+)/K(+)-ATPase with Glycolysis Demonstrated in Permeabilized Rat Cardiomyocytes
por: Sepp, Mervi, et al.
Publicado: (2014)

An Apical MRCK-driven Morphogenetic Pathway Controls Epithelial Polarity
por: Zihni, Ceniz, et al.
Publicado: (2017)

Ouabain Stimulates a Na(+)/K(+)-ATPase-Mediated SFK-Activated Signalling Pathway That Regulates Tight Junction Function in the Mouse Blastocyst
por: Giannatselis, Holly, et al.
Publicado: (2011)

Multiple Na,K-ATPase Subunits Colocalize in the Brush Border of Mouse Choroid Plexus Epithelial Cells
por: Baasch Christensen, Inga, et al.
Publicado: (2021)

The β Subunit of the Na(+)/K(+)-ATPase Follows the Conformational State of the Holoenzyme
por: Dempski, Robert E., et al.
Publicado: (2005)

Regulation of Cardiac Contractility by the Alpha 2 Subunit of the Na(+)/K(+)-ATPase
por: Skogestad, Jonas, et al.
Publicado: (2022)

Involvement of zebrafish Na(+),K(+) ATPase in myocardial cell junction maintenance
por: Cibrián-Uhalte, Elena, et al.
Publicado: (2007)

The Na, K-ATPase β-Subunit Isoforms Expression in Glioblastoma Multiforme: Moonlighting Roles
por: Rotoli, Deborah, et al.
Publicado: (2017)

Maturation of the catalytic alpha-subunit of Na,K-ATPase during intracellular transport
Publicado: (1987)

The Polarized Distribution of Na(+),K(+)-ATPase: Role of the Interaction between β Subunits
por: Padilla-Benavides, Teresita, et al.
Publicado: (2010)

Bioinformatics approaches for classification and investigation of the evolution of the Na/K-ATPase alpha-subunit
por: Shahnazari, Marzieh, et al.
Publicado: (2022)

Na+ and K+ transport at basolateral membranes of epithelial cells. I. Stoichiometry of the Na,K-ATPase
Publicado: (1986)

MRCK: a master regulator of tissue remodeling or another ‘ROCK’ in the epithelial block?
por: Zihni, Ceniz
Publicado: (2021)

Neuroglian, Gliotactin, and the Na(+)/K(+) ATPase are essential for septate junction function in Drosophila
por: Genova, Jennifer L., et al.
Publicado: (2003)

Na+ and K+ transport at basolateral membranes of epithelial cells. II. K+ efflux and stoichiometry of the Na,K-ATPase
Publicado: (1986)

The adhesion molecule on glia (AMOG) is a homologue of the beta subunit of the Na,K-ATPase
Publicado: (1990)

Flexible selection of diversified Na(+)/K(+)-ATPase α-subunit isoforms for osmoregulation in teleosts
por: Wong, Marty Kwok-Shing, et al.
Publicado: (2016)

The Apical Localization of Na(+), K(+)-ATPase in Cultured Human Retinal Pigment Epithelial Cells Depends on Expression of the β(2) Subunit
por: Lobato-Álvarez, Jorge A., et al.
Publicado: (2016)

Hypercapnia Impairs Na,K-ATPase Function by Inducing Endoplasmic Reticulum Retention of the β-Subunit of the Enzyme in Alveolar Epithelial Cells
por: Kryvenko, Vitalii, et al.
Publicado: (2020)

Protein Carbonylation of an Amino Acid Residue of the Na/K‐ATPase α1 Subunit Determines Na/K‐ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells
por: Yan, Yanling, et al.
Publicado: (2016)

Oligomerization and maturation of Na,K-ATPase: functional interaction of the cytoplasmic NH2 terminus of the beta subunit with the alpha subunit
Publicado: (1996)

Expression and Trafficking of the γ Subunit of Na,K-ATPase in Hypertonically Challenged IMCD3 Cells
por: Pihakaski-Maunsbach, Kaarina, et al.
Publicado: (2008)

The alpha and beta subunits of the Na,K-ATPase can assemble at the plasma membrane into functional enzyme
Publicado: (1994)

Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications
Publicado: (1987)

Localization of Na+,K+-ATPase alpha-subunit to the sinusoidal and lateral but not canalicular membranes of rat hepatocytes
Publicado: (1987)

Na(+)/K(+)-ATPase α1 subunit, a novel therapeutic target for hepatocellular carcinoma
por: Zhuang, Liping, et al.
Publicado: (2015)

The β(2)-Subunit (AMOG) of Human Na(+), K(+)-ATPase Is a Homophilic Adhesion Molecule
por: Roldán, María Luisa, et al.
Publicado: (2022)

Bioinformatic Analysis of Na(+), K(+)-ATPase Regulation through Phosphorylation of the Alpha-Subunit N-Terminus
por: Blayney, Emma-Lucille, et al.
Publicado: (2022)

Managing Brain Extracellular K(+) during Neuronal Activity: The Physiological Role of the Na(+)/K(+)-ATPase Subunit Isoforms
por: Larsen, Brian Roland, et al.
Publicado: (2016)

MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion
por: Gagliardi, Paolo Armando, et al.
Publicado: (2018)

MRCKα is a novel regulator of prolactin-induced lactogenesis in bovine mammary epithelial cells
por: Wang, Fang, et al.
Publicado: (2022)

Oxidant effects on epithelial Na,K-ATPase gene expression and promoter function.
por: Wendt, C H, et al.
Publicado: (1998)

Mechanism of Na-K-ATPase Inhibition by PGE2 in Intestinal Epithelial Cells
por: Nepal, Niraj, et al.
Publicado: (2021)

Transcriptional Regulators of Claudins in Epithelial Tight Junctions
por: Khan, Niamat, et al.
Publicado: (2015)

Implications of AMPK in the Formation of Epithelial Tight Junctions
por: Rowart, Pascal, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3equs3h31fkd9br7j6cas2rdb3