IL-6 and other biomarkers as predictors of severity in COVID-19

OBJECTIVE: Cytokine release syndrome is suggested to be the most important mechanism triggering acute respiratory distress syndrome and end organ damage in COVID-19. The severity of disease may be measured by different biomarkers. METHODS: We studied markers of inflammation and coagulation as record...

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Detalles Bibliográficos
Autores principales: Broman, N., Rantasärkkä, K., Feuth, T., Valtonen, M., Waris, M., Hohenthal, U., Rintala, E., Karlsson, A., Marttila, H., Peltola, V., Vuorinen, T., Oksi, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Infectious Diseases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935117/
https://www.ncbi.nlm.nih.gov/pubmed/33305624
http://dx.doi.org/10.1080/07853890.2020.1840621
Descripción
Sumario:OBJECTIVE: Cytokine release syndrome is suggested to be the most important mechanism triggering acute respiratory distress syndrome and end organ damage in COVID-19. The severity of disease may be measured by different biomarkers. METHODS: We studied markers of inflammation and coagulation as recorded in 29 patients on admission to the hospital in order to identify markers of severe COVID-19 and need of ICU. RESULTS: Patients who were eventually admitted to ICU displayed significantly higher serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin. No statistical differences were found between the groups in median levels of lymphocytes, D-dimer or ferritin. CONCLUSIONS: IL-6 and CRP were the strongest predictors of severity in hospitalized patients with COVID-19.

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