IL-6 and other biomarkers as predictors of severity in COVID-19

OBJECTIVE: Cytokine release syndrome is suggested to be the most important mechanism triggering acute respiratory distress syndrome and end organ damage in COVID-19. The severity of disease may be measured by different biomarkers. METHODS: We studied markers of inflammation and coagulation as record...

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Autores principales: Broman, N., Rantasärkkä, K., Feuth, T., Valtonen, M., Waris, M., Hohenthal, U., Rintala, E., Karlsson, A., Marttila, H., Peltola, V., Vuorinen, T., Oksi, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Infectious Diseases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935117/
https://www.ncbi.nlm.nih.gov/pubmed/33305624
http://dx.doi.org/10.1080/07853890.2020.1840621
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author Broman, N.
Rantasärkkä, K.
Feuth, T.
Valtonen, M.
Waris, M.
Hohenthal, U.
Rintala, E.
Karlsson, A.
Marttila, H.
Peltola, V.
Vuorinen, T.
Oksi, J.
author_facet Broman, N.
Rantasärkkä, K.
Feuth, T.
Valtonen, M.
Waris, M.
Hohenthal, U.
Rintala, E.
Karlsson, A.
Marttila, H.
Peltola, V.
Vuorinen, T.
Oksi, J.
author_sort Broman, N.
collection PubMed
description OBJECTIVE: Cytokine release syndrome is suggested to be the most important mechanism triggering acute respiratory distress syndrome and end organ damage in COVID-19. The severity of disease may be measured by different biomarkers. METHODS: We studied markers of inflammation and coagulation as recorded in 29 patients on admission to the hospital in order to identify markers of severe COVID-19 and need of ICU. RESULTS: Patients who were eventually admitted to ICU displayed significantly higher serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin. No statistical differences were found between the groups in median levels of lymphocytes, D-dimer or ferritin. CONCLUSIONS: IL-6 and CRP were the strongest predictors of severity in hospitalized patients with COVID-19.
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spelling pubmed-79351172021-03-11 IL-6 and other biomarkers as predictors of severity in COVID-19 Broman, N. Rantasärkkä, K. Feuth, T. Valtonen, M. Waris, M. Hohenthal, U. Rintala, E. Karlsson, A. Marttila, H. Peltola, V. Vuorinen, T. Oksi, J. Ann Med Infectious Diseases OBJECTIVE: Cytokine release syndrome is suggested to be the most important mechanism triggering acute respiratory distress syndrome and end organ damage in COVID-19. The severity of disease may be measured by different biomarkers. METHODS: We studied markers of inflammation and coagulation as recorded in 29 patients on admission to the hospital in order to identify markers of severe COVID-19 and need of ICU. RESULTS: Patients who were eventually admitted to ICU displayed significantly higher serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin. No statistical differences were found between the groups in median levels of lymphocytes, D-dimer or ferritin. CONCLUSIONS: IL-6 and CRP were the strongest predictors of severity in hospitalized patients with COVID-19. Taylor & Francis 2021-03-04 /pmc/articles/PMC7935117/ /pubmed/33305624 http://dx.doi.org/10.1080/07853890.2020.1840621 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Infectious Diseases
Broman, N.
Rantasärkkä, K.
Feuth, T.
Valtonen, M.
Waris, M.
Hohenthal, U.
Rintala, E.
Karlsson, A.
Marttila, H.
Peltola, V.
Vuorinen, T.
Oksi, J.
IL-6 and other biomarkers as predictors of severity in COVID-19
title IL-6 and other biomarkers as predictors of severity in COVID-19
title_full IL-6 and other biomarkers as predictors of severity in COVID-19
title_fullStr IL-6 and other biomarkers as predictors of severity in COVID-19
title_full_unstemmed IL-6 and other biomarkers as predictors of severity in COVID-19
title_short IL-6 and other biomarkers as predictors of severity in COVID-19
title_sort il-6 and other biomarkers as predictors of severity in covid-19
topic Infectious Diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935117/
https://www.ncbi.nlm.nih.gov/pubmed/33305624
http://dx.doi.org/10.1080/07853890.2020.1840621
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