Cargando…

Autocrine and paracrine interferon signalling as ‘ring vaccination’ and ‘contact tracing’ strategies to suppress virus infection in a host

The innate immune response, particularly the interferon response, represents a first line of defence against viral infections. The interferon molecules produced from infected cells act through autocrine and paracrine signalling to turn host cells into an antiviral state. Although the molecular mecha...

Descripción completa

Detalles Bibliográficos
Autores principales: Michael Lavigne, G., Russell, Hayley, Sherry, Barbara, Ke, Ruian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935137/
https://www.ncbi.nlm.nih.gov/pubmed/33622135
http://dx.doi.org/10.1098/rspb.2020.3002
_version_ 1783660944407134208
author Michael Lavigne, G.
Russell, Hayley
Sherry, Barbara
Ke, Ruian
author_facet Michael Lavigne, G.
Russell, Hayley
Sherry, Barbara
Ke, Ruian
author_sort Michael Lavigne, G.
collection PubMed
description The innate immune response, particularly the interferon response, represents a first line of defence against viral infections. The interferon molecules produced from infected cells act through autocrine and paracrine signalling to turn host cells into an antiviral state. Although the molecular mechanisms of IFN signalling have been well characterized, how the interferon response collectively contribute to the regulation of host cells to stop or suppress viral infection during early infection remain unclear. Here, we use mathematical models to delineate the roles of the autocrine and the paracrine signalling, and show that their impacts on viral spread are dependent on how infection proceeds. In particular, we found that when infection is well-mixed, the paracrine signalling is not as effective; by contrast, when infection spreads in a spatial manner, a likely scenario during initial infection in tissue, the paracrine signalling can impede the spread of infection by decreasing the number of susceptible cells close to the site of infection. Furthermore, we argue that the interferon response can be seen as a parallel to population-level epidemic prevention strategies such as ‘contact tracing’ or ‘ring vaccination’. Thus, our results here may have implications for the outbreak control at the population scale more broadly.
format Online
Article
Text
id pubmed-7935137
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Royal Society
record_format MEDLINE/PubMed
spelling pubmed-79351372021-04-10 Autocrine and paracrine interferon signalling as ‘ring vaccination’ and ‘contact tracing’ strategies to suppress virus infection in a host Michael Lavigne, G. Russell, Hayley Sherry, Barbara Ke, Ruian Proc Biol Sci Ecology The innate immune response, particularly the interferon response, represents a first line of defence against viral infections. The interferon molecules produced from infected cells act through autocrine and paracrine signalling to turn host cells into an antiviral state. Although the molecular mechanisms of IFN signalling have been well characterized, how the interferon response collectively contribute to the regulation of host cells to stop or suppress viral infection during early infection remain unclear. Here, we use mathematical models to delineate the roles of the autocrine and the paracrine signalling, and show that their impacts on viral spread are dependent on how infection proceeds. In particular, we found that when infection is well-mixed, the paracrine signalling is not as effective; by contrast, when infection spreads in a spatial manner, a likely scenario during initial infection in tissue, the paracrine signalling can impede the spread of infection by decreasing the number of susceptible cells close to the site of infection. Furthermore, we argue that the interferon response can be seen as a parallel to population-level epidemic prevention strategies such as ‘contact tracing’ or ‘ring vaccination’. Thus, our results here may have implications for the outbreak control at the population scale more broadly. The Royal Society 2021-02-24 2021-02-24 /pmc/articles/PMC7935137/ /pubmed/33622135 http://dx.doi.org/10.1098/rspb.2020.3002 Text en © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Ecology
Michael Lavigne, G.
Russell, Hayley
Sherry, Barbara
Ke, Ruian
Autocrine and paracrine interferon signalling as ‘ring vaccination’ and ‘contact tracing’ strategies to suppress virus infection in a host
title Autocrine and paracrine interferon signalling as ‘ring vaccination’ and ‘contact tracing’ strategies to suppress virus infection in a host
title_full Autocrine and paracrine interferon signalling as ‘ring vaccination’ and ‘contact tracing’ strategies to suppress virus infection in a host
title_fullStr Autocrine and paracrine interferon signalling as ‘ring vaccination’ and ‘contact tracing’ strategies to suppress virus infection in a host
title_full_unstemmed Autocrine and paracrine interferon signalling as ‘ring vaccination’ and ‘contact tracing’ strategies to suppress virus infection in a host
title_short Autocrine and paracrine interferon signalling as ‘ring vaccination’ and ‘contact tracing’ strategies to suppress virus infection in a host
title_sort autocrine and paracrine interferon signalling as ‘ring vaccination’ and ‘contact tracing’ strategies to suppress virus infection in a host
topic Ecology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935137/
https://www.ncbi.nlm.nih.gov/pubmed/33622135
http://dx.doi.org/10.1098/rspb.2020.3002
work_keys_str_mv AT michaellavigneg autocrineandparacrineinterferonsignallingasringvaccinationandcontacttracingstrategiestosuppressvirusinfectioninahost
AT russellhayley autocrineandparacrineinterferonsignallingasringvaccinationandcontacttracingstrategiestosuppressvirusinfectioninahost
AT sherrybarbara autocrineandparacrineinterferonsignallingasringvaccinationandcontacttracingstrategiestosuppressvirusinfectioninahost
AT keruian autocrineandparacrineinterferonsignallingasringvaccinationandcontacttracingstrategiestosuppressvirusinfectioninahost