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The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature
BACKGROUND: Multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB) and human immunodeficiency virus (HIV) co-infection are a deadly combination. While evidence on the effects of HIV co-infection on MDR/RR-TB treatment outcomes is well-documented, little published evidence describes the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935310/ https://www.ncbi.nlm.nih.gov/pubmed/33667271 http://dx.doi.org/10.1371/journal.pone.0248174 |
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author | Geiger, Keri Stamper, Paul D. Farley, Jason E. |
author_facet | Geiger, Keri Stamper, Paul D. Farley, Jason E. |
author_sort | Geiger, Keri |
collection | PubMed |
description | BACKGROUND: Multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB) and human immunodeficiency virus (HIV) co-infection are a deadly combination. While evidence on the effects of HIV co-infection on MDR/RR-TB treatment outcomes is well-documented, little published evidence describes the effects of MDR/RR-TB treatment on HIV disease. METHODS: We conducted a review of literature published prior to June 2020. We searched Pubmed, CINAHL, and EMBASE using variations of the terms “multidrug-resistant tuberculosis,” “HIV,” and either “CD4” or “viral load.” Two reviewers independently completed title and abstract screening, full-text screening, article evaluation, and data extraction. We also included five published articles evaluated as evidence by the World Health Organization (WHO) in preparation for the 2019 MDR/RR-TB treatment guideline update. RESULTS: A total of 459 references were returned, with 362 remaining after duplicate removal. Following article screening, six manuscripts were included. Articles reported CD4 count and/or viral load results for MDR/RR-TB and HIV co-infected patients during and/or after MDR/RR-TB treatment. The additional five references identified from the WHO guideline revision did not report HIV disease indicators after MDR/RR-TB initiation. CONCLUSION: There is a paucity of evidence on HIV disease indicators following MDR/RR-TB treatment. Researchers should report longitudinal HIV disease indicators in co-infected patients in publications. |
format | Online Article Text |
id | pubmed-7935310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-79353102021-03-15 The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature Geiger, Keri Stamper, Paul D. Farley, Jason E. PLoS One Research Article BACKGROUND: Multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB) and human immunodeficiency virus (HIV) co-infection are a deadly combination. While evidence on the effects of HIV co-infection on MDR/RR-TB treatment outcomes is well-documented, little published evidence describes the effects of MDR/RR-TB treatment on HIV disease. METHODS: We conducted a review of literature published prior to June 2020. We searched Pubmed, CINAHL, and EMBASE using variations of the terms “multidrug-resistant tuberculosis,” “HIV,” and either “CD4” or “viral load.” Two reviewers independently completed title and abstract screening, full-text screening, article evaluation, and data extraction. We also included five published articles evaluated as evidence by the World Health Organization (WHO) in preparation for the 2019 MDR/RR-TB treatment guideline update. RESULTS: A total of 459 references were returned, with 362 remaining after duplicate removal. Following article screening, six manuscripts were included. Articles reported CD4 count and/or viral load results for MDR/RR-TB and HIV co-infected patients during and/or after MDR/RR-TB treatment. The additional five references identified from the WHO guideline revision did not report HIV disease indicators after MDR/RR-TB initiation. CONCLUSION: There is a paucity of evidence on HIV disease indicators following MDR/RR-TB treatment. Researchers should report longitudinal HIV disease indicators in co-infected patients in publications. Public Library of Science 2021-03-05 /pmc/articles/PMC7935310/ /pubmed/33667271 http://dx.doi.org/10.1371/journal.pone.0248174 Text en © 2021 Geiger et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Geiger, Keri Stamper, Paul D. Farley, Jason E. The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature |
title | The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature |
title_full | The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature |
title_fullStr | The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature |
title_full_unstemmed | The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature |
title_short | The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature |
title_sort | effects of mdr/rr-tb treatment on hiv disease: a systematic review of literature |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935310/ https://www.ncbi.nlm.nih.gov/pubmed/33667271 http://dx.doi.org/10.1371/journal.pone.0248174 |
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