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The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature

BACKGROUND: Multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB) and human immunodeficiency virus (HIV) co-infection are a deadly combination. While evidence on the effects of HIV co-infection on MDR/RR-TB treatment outcomes is well-documented, little published evidence describes the...

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Autores principales: Geiger, Keri, Stamper, Paul D., Farley, Jason E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935310/
https://www.ncbi.nlm.nih.gov/pubmed/33667271
http://dx.doi.org/10.1371/journal.pone.0248174
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author Geiger, Keri
Stamper, Paul D.
Farley, Jason E.
author_facet Geiger, Keri
Stamper, Paul D.
Farley, Jason E.
author_sort Geiger, Keri
collection PubMed
description BACKGROUND: Multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB) and human immunodeficiency virus (HIV) co-infection are a deadly combination. While evidence on the effects of HIV co-infection on MDR/RR-TB treatment outcomes is well-documented, little published evidence describes the effects of MDR/RR-TB treatment on HIV disease. METHODS: We conducted a review of literature published prior to June 2020. We searched Pubmed, CINAHL, and EMBASE using variations of the terms “multidrug-resistant tuberculosis,” “HIV,” and either “CD4” or “viral load.” Two reviewers independently completed title and abstract screening, full-text screening, article evaluation, and data extraction. We also included five published articles evaluated as evidence by the World Health Organization (WHO) in preparation for the 2019 MDR/RR-TB treatment guideline update. RESULTS: A total of 459 references were returned, with 362 remaining after duplicate removal. Following article screening, six manuscripts were included. Articles reported CD4 count and/or viral load results for MDR/RR-TB and HIV co-infected patients during and/or after MDR/RR-TB treatment. The additional five references identified from the WHO guideline revision did not report HIV disease indicators after MDR/RR-TB initiation. CONCLUSION: There is a paucity of evidence on HIV disease indicators following MDR/RR-TB treatment. Researchers should report longitudinal HIV disease indicators in co-infected patients in publications.
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spelling pubmed-79353102021-03-15 The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature Geiger, Keri Stamper, Paul D. Farley, Jason E. PLoS One Research Article BACKGROUND: Multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB) and human immunodeficiency virus (HIV) co-infection are a deadly combination. While evidence on the effects of HIV co-infection on MDR/RR-TB treatment outcomes is well-documented, little published evidence describes the effects of MDR/RR-TB treatment on HIV disease. METHODS: We conducted a review of literature published prior to June 2020. We searched Pubmed, CINAHL, and EMBASE using variations of the terms “multidrug-resistant tuberculosis,” “HIV,” and either “CD4” or “viral load.” Two reviewers independently completed title and abstract screening, full-text screening, article evaluation, and data extraction. We also included five published articles evaluated as evidence by the World Health Organization (WHO) in preparation for the 2019 MDR/RR-TB treatment guideline update. RESULTS: A total of 459 references were returned, with 362 remaining after duplicate removal. Following article screening, six manuscripts were included. Articles reported CD4 count and/or viral load results for MDR/RR-TB and HIV co-infected patients during and/or after MDR/RR-TB treatment. The additional five references identified from the WHO guideline revision did not report HIV disease indicators after MDR/RR-TB initiation. CONCLUSION: There is a paucity of evidence on HIV disease indicators following MDR/RR-TB treatment. Researchers should report longitudinal HIV disease indicators in co-infected patients in publications. Public Library of Science 2021-03-05 /pmc/articles/PMC7935310/ /pubmed/33667271 http://dx.doi.org/10.1371/journal.pone.0248174 Text en © 2021 Geiger et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Geiger, Keri
Stamper, Paul D.
Farley, Jason E.
The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature
title The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature
title_full The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature
title_fullStr The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature
title_full_unstemmed The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature
title_short The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature
title_sort effects of mdr/rr-tb treatment on hiv disease: a systematic review of literature
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935310/
https://www.ncbi.nlm.nih.gov/pubmed/33667271
http://dx.doi.org/10.1371/journal.pone.0248174
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