Cargando…

PD-L1(+) neutrophils contribute to injury-induced infection susceptibility

The underlying mechanisms contributing to injury-induced infection susceptibility remain poorly understood. Here, we describe a rapid increase in neutrophil cell numbers in the lungs following induction of thermal injury. These neutrophils expressed elevated levels of programmed death ligand 1 (PD-L...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thanabalasuriar, Ajitha, Chiang, Abby J., Morehouse, Christopher, Camara, Margarita, Hawkins, Shonda, Keller, Ashley E., Koksal, Adem C., Caceres, Carolina S., Berlin, Aaron A., Holoweckyj, Nicholas, Takahashi, Virginia N., Cheng, Lily, de los Reyes, Melissa, Pelletier, Mark, Patera, Andriani C., Sellman, Bret, Hess, Sonja, Marelli, Marcello, Boo, Chelsea C., Cohen, Taylor S., DiGiandomenico, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935370/ https://www.ncbi.nlm.nih.gov/pubmed/33674305 http://dx.doi.org/10.1126/sciadv.abd9436

Ejemplares similares

Resident macrophages of the lung and liver: The guardians of our tissues
por: Kulle, Amelia, et al.
Publicado: (2022)

Engraftment of Bacteria after Fecal Microbiota Transplantation Is Dependent on Both Frequency of Dosing and Duration of Preparative Antibiotic Regimen
por: Gopalakrishnan, Vancheswaran, et al.
Publicado: (2021)

Microbiome Modulation as a Novel Strategy to Treat and Prevent Respiratory Infections
por: Mindt, Barbara C., et al.
Publicado: (2022)

Unraveling the host's immune response to infection: Seeing is believing
por: Scott, Brittney N.V., et al.
Publicado: (2019)

Treatment Efficacy of MEDI3902 in Pseudomonas aeruginosa Bloodstream Infection and Acute Pneumonia Rabbit Models
por: Le, Hoan N., et al.
Publicado: (2019)

MEDI3902 Correlates of Protection against Severe Pseudomonas aeruginosa Pneumonia in a Rabbit Acute Pneumonia Model
por: Le, Hoan N., et al.
Publicado: (2018)

Multifunctional Monoclonal Antibody Targeting Pseudomonas aeruginosa Keratitis in Mice
por: Hebert, Wesley, et al.
Publicado: (2020)

Antivirulence Bispecific Monoclonal Antibody-Mediated Protection against Pseudomonas aeruginosa Ventilator-Associated Pneumonia in a Rabbit Model
por: Aguiar-Alves, Fábio, et al.
Publicado: (2022)

Early diagnostic BioMARKers in exacerbations of chronic obstructive pulmonary disease: protocol of the exploratory, prospective, longitudinal, single-centre, observational MARKED study
por: Waeijen-Smit, Kiki, et al.
Publicado: (2023)

A Science-Based Methodology Framework for the Assessment of Combination Safety Risks in Clinical Trials
por: Patera, Andriani C., et al.
Publicado: (2023)

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature
por: Kolaczkowska, Elzbieta, et al.
Publicado: (2015)

A Pseudomonas aeruginosa-Derived Particulate Vaccine Protects against P. aeruginosa Infection
por: Gonzaga, Zennia Jean C., et al.
Publicado: (2021)

Unmet needs in the management of exacerbations of chronic obstructive pulmonary disease
por: Waeijen-Smit, Kiki, et al.
Publicado: (2021)

R-Spondin 2 signaling mediates susceptibility to fatal infectious diarrhea
por: Papapietro, Olivier, et al.
Publicado: (2013)

Respiratory syncytial virus infection is associated with an altered innate immunity and a heightened pro-inflammatory response in the lungs of preterm lambs
por: Sow, Fatoumata B, et al.
Publicado: (2011)

Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae
por: Pennini, Meghan E., et al.
Publicado: (2017)

Anti-Psl Targeting of Pseudomonas aeruginosa Biofilms for Neutrophil-Mediated Disruption
por: Ray, Valerie A., et al.
Publicado: (2017)

Publisher Correction: Anti-Psl Targeting of Pseudomonas aeruginosa Biofilms for Neutrophil-Mediated Disruption
por: Ray, Valerie A., et al.
Publicado: (2018)

The “Genomic Storm” Induced by Bacterial Endotoxin Is Calmed by a Nuclear Transport Modifier That Attenuates Localized and Systemic Inflammation
por: DiGiandomenico, Antonio, et al.
Publicado: (2014)

Biopsychosocial factors associated with complications in patients with frostbite
por: Endorf, Frederick W., et al.
Publicado: (2022)

Frontline Science: Employing enzymatic treatment options for management of ocular biofilm‐based infections
por: Kugadas, Abirami, et al.
Publicado: (2019)

Differential Expression and Roles of Staphylococcus aureus Virulence Determinants during Colonization and Disease
por: Jenkins, Amy, et al.
Publicado: (2015)

Anti-MrkA Monoclonal Antibodies Reveal Distinct Structural and Antigenic Features of MrkA
por: Wang, Qun, et al.
Publicado: (2017)

Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient
por: Rao, Jayasimha, et al.
Publicado: (2011)

RAGE inhibits human respiratory syncytial virus syncytium formation by interfering with F-protein function
por: Tian, Jane, et al.
Publicado: (2013)

Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin
por: Chan, Keefe T., et al.
Publicado: (2012)

S. aureus blocks efferocytosis of neutrophils by macrophages through the activity of its virulence factor alpha toxin
por: Cohen, Taylor S., et al.
Publicado: (2016)

Using a community-based participatory research approach to meaningfully engage those with lived experience of diabetes and homelessness
por: Campbell, David J T, et al.
Publicado: (2021)

Deep Camera–Radar Fusion with an Attention Framework for Autonomous Vehicle Vision in Foggy Weather Conditions
por: Ogunrinde, Isaac, et al.
Publicado: (2023)

The challenges of managing diabetes while homeless: a qualitative study using photovoice methodology
por: Campbell, Rachel B., et al.
Publicado: (2021)

Les défis de la gestion du diabète chez les personnes itinérantes : étude qualitative avec la méthode photovoix
por: Campbell, Rachel B., et al.
Publicado: (2021)

Monoclonal antibodies neutralizing alpha-hemolysin, bicomponent leukocidins, and clumping factor A protected against Staphylococcus aureus-induced acute circulatory failure in a mechanically ventilated rabbit model of hyperdynamic septic shock
por: Nguyen, Nhu T. Q., et al.
Publicado: (2023)

683. Understanding Clostridioides difficile toxinB gene conservation through surveillance of public data
por: Mulholland, Kelly, et al.
Publicado: (2023)

Recombinant Salmonella Expressing Burkholderia mallei LPS O Antigen Provides Protection in a Murine Model of Melioidosis and Glanders
por: Moustafa, Dina A., et al.
Publicado: (2015)

Efficacy of a Pseudomonas aeruginosa Serogroup O9 Vaccine
por: Moustafa, Dina A., et al.
Publicado: (2023)

A case report: use of cerebral oximetry in the early detection of cerebral hypoperfusion in a post-cardiac arrest patient during targeted temperature management
por: Ng, Shonda, et al.
Publicado: (2019)

Identification of broadly protective human antibodies to Pseudomonas aeruginosa exopolysaccharide Psl by phenotypic screening
por: DiGiandomenico, Antonio, et al.
Publicado: (2012)

Candida albicans Augments Staphylococcus aureus Virulence by Engaging the Staphylococcal agr Quorum Sensing System
por: Todd, Olivia A., et al.
Publicado: (2019)

An Investigation into the Effects of Electric Field Uniformity on Electrospun TPU Fiber Nano-Scale Morphology
por: Morehouse, Aaron, et al.
Publicado: (2023)

Neutralizing Staphylococcus aureus Virulence with AZD6389, a Three mAb Combination, Accelerates Closure of a Diabetic Polymicrobial Wound
por: Tkaczyk, Christine, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1c8usicid663tu045bmaal59ge