The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity

The antihelmintic drug ABZ and its metabolites belong to the chemical family of benzimidazoles (BZM) that act as potent tubulin polymerization inhibitors, suggesting a potential re-direction of BZMs for cancer therapy. Applying UV-Vis spectrometry we here demonstrate ABZ as a DNA intercalator. This...

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Detalles Bibliográficos
Autores principales: Will Castro, Luiza S. E. P., Pieters, Wietske, Alemdehy, Mir Farshid, Aslam, Muhammad A., Buoninfante, Olimpia Alessandra, Raaijmakers, Jonne A., Pilzecker, Bas, van den Berk, Paul C. M., te Riele, Hein, Medema, René H., Pedrosa, Rozangela C., Jacobs, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935534/
https://www.ncbi.nlm.nih.gov/pubmed/33679394
http://dx.doi.org/10.3389/fphar.2021.596535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935534/
https://www.ncbi.nlm.nih.gov/pubmed/33679394
http://dx.doi.org/10.3389/fphar.2021.596535

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