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Advances for the Hepatitis A Virus Antigen Production Using a Virus Strain With Codon Frequency Optimization Adjustments in Specific Locations

The available cell-adapted hepatitis A virus (HAV) strains show a very slow replication phenotype hampering the affordable production of antigen. A fast-growing strain characterized by the occurrence of mutations in the internal ribosome entry site (IRES), combined with changes in the codon composit...

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Detalles Bibliográficos
Autores principales:	Chavarria-Miró, Gemma, de Castellarnau, Montserrat, Fuentes, Cristina, D’Andrea, Lucía, Pérez-Rodríguez, Francisco-Javier, Beguiristain, Nerea, Bosch, Albert, Guix, Susana, Pintó, Rosa M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935560/ https://www.ncbi.nlm.nih.gov/pubmed/33679679 http://dx.doi.org/10.3389/fmicb.2021.642267

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