Application of Single-Cell Approaches to Study Myeloproliferative Neoplasm Biology

Philadelphia-negative myeloproliferative neoplasms (MPNs) are an excellent tractable disease model of a number of aspects of human cancer biology, including genetic evolution, tissue-associated fibrosis, and cancer stem cells. In this review, we discuss recent insights into MPN biology gained from t...

Descripción completa

Detalles Bibliográficos
Autores principales: Royston, Daniel, Mead, Adam J., Psaila, Bethan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Health Science 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935666/
https://www.ncbi.nlm.nih.gov/pubmed/33641869
http://dx.doi.org/10.1016/j.hoc.2021.01.002
_version_ 1783661047940382720
author Royston, Daniel
Mead, Adam J.
Psaila, Bethan
author_facet Royston, Daniel
Mead, Adam J.
Psaila, Bethan
author_sort Royston, Daniel
collection PubMed
description Philadelphia-negative myeloproliferative neoplasms (MPNs) are an excellent tractable disease model of a number of aspects of human cancer biology, including genetic evolution, tissue-associated fibrosis, and cancer stem cells. In this review, we discuss recent insights into MPN biology gained from the application of a number of new single-cell technologies to study human disease, with a specific focus on single-cell genomics, single-cell transcriptomics, and digital pathology.
format Online
Article
Text
id pubmed-7935666
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier Health Science
record_format MEDLINE/PubMed
spelling pubmed-79356662021-04-01 Application of Single-Cell Approaches to Study Myeloproliferative Neoplasm Biology Royston, Daniel Mead, Adam J. Psaila, Bethan Hematol Oncol Clin North Am Article Philadelphia-negative myeloproliferative neoplasms (MPNs) are an excellent tractable disease model of a number of aspects of human cancer biology, including genetic evolution, tissue-associated fibrosis, and cancer stem cells. In this review, we discuss recent insights into MPN biology gained from the application of a number of new single-cell technologies to study human disease, with a specific focus on single-cell genomics, single-cell transcriptomics, and digital pathology. Elsevier Health Science 2021-04 /pmc/articles/PMC7935666/ /pubmed/33641869 http://dx.doi.org/10.1016/j.hoc.2021.01.002 Text en © 2021 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Royston, Daniel
Mead, Adam J.
Psaila, Bethan
Application of Single-Cell Approaches to Study Myeloproliferative Neoplasm Biology
title Application of Single-Cell Approaches to Study Myeloproliferative Neoplasm Biology
title_full Application of Single-Cell Approaches to Study Myeloproliferative Neoplasm Biology
title_fullStr Application of Single-Cell Approaches to Study Myeloproliferative Neoplasm Biology
title_full_unstemmed Application of Single-Cell Approaches to Study Myeloproliferative Neoplasm Biology
title_short Application of Single-Cell Approaches to Study Myeloproliferative Neoplasm Biology
title_sort application of single-cell approaches to study myeloproliferative neoplasm biology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935666/
https://www.ncbi.nlm.nih.gov/pubmed/33641869
http://dx.doi.org/10.1016/j.hoc.2021.01.002
work_keys_str_mv AT roystondaniel applicationofsinglecellapproachestostudymyeloproliferativeneoplasmbiology
AT meadadamj applicationofsinglecellapproachestostudymyeloproliferativeneoplasmbiology
AT psailabethan applicationofsinglecellapproachestostudymyeloproliferativeneoplasmbiology

Ejemplares similares