Etoricoxib may inhibit cytokine storm to treat COVID-19

The worldwide spread of COVID-19 has caused an unprecedented disaster. The emergence of COVID-19-mediated cytokine storm is one of the most important contributors to the development of acute and severe illness in patients. At present, there is an urgent need for drugs that can inhibit cytokine storm...

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Detalles Bibliográficos
Autor principal: Wang, Ruo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935670/
https://www.ncbi.nlm.nih.gov/pubmed/33730601
http://dx.doi.org/10.1016/j.mehy.2021.110557
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author Wang, Ruo
author_facet Wang, Ruo
author_sort Wang, Ruo
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description The worldwide spread of COVID-19 has caused an unprecedented disaster. The emergence of COVID-19-mediated cytokine storm is one of the most important contributors to the development of acute and severe illness in patients. At present, there is an urgent need for drugs that can inhibit cytokine storm to treat COVID-19. In the absence of specific drugs and vaccines, it is important to screen existing drugs as potential treatments. This article introduces a potential repositioning of the existing drug etoricoxib, which may inhibit cytokine storm to treat COVID-19 through reducing the activity of Cyclooxygenase-2 in the conversion of arachidonic acid to prostaglandin.
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spelling pubmed-79356702021-03-08 Etoricoxib may inhibit cytokine storm to treat COVID-19 Wang, Ruo Med Hypotheses Article The worldwide spread of COVID-19 has caused an unprecedented disaster. The emergence of COVID-19-mediated cytokine storm is one of the most important contributors to the development of acute and severe illness in patients. At present, there is an urgent need for drugs that can inhibit cytokine storm to treat COVID-19. In the absence of specific drugs and vaccines, it is important to screen existing drugs as potential treatments. This article introduces a potential repositioning of the existing drug etoricoxib, which may inhibit cytokine storm to treat COVID-19 through reducing the activity of Cyclooxygenase-2 in the conversion of arachidonic acid to prostaglandin. Elsevier Ltd. 2021-05 2021-03-06 /pmc/articles/PMC7935670/ /pubmed/33730601 http://dx.doi.org/10.1016/j.mehy.2021.110557 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Wang, Ruo
Etoricoxib may inhibit cytokine storm to treat COVID-19
title Etoricoxib may inhibit cytokine storm to treat COVID-19
title_full Etoricoxib may inhibit cytokine storm to treat COVID-19
title_fullStr Etoricoxib may inhibit cytokine storm to treat COVID-19
title_full_unstemmed Etoricoxib may inhibit cytokine storm to treat COVID-19
title_short Etoricoxib may inhibit cytokine storm to treat COVID-19
title_sort etoricoxib may inhibit cytokine storm to treat covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935670/
https://www.ncbi.nlm.nih.gov/pubmed/33730601
http://dx.doi.org/10.1016/j.mehy.2021.110557
work_keys_str_mv AT wangruo etoricoxibmayinhibitcytokinestormtotreatcovid19

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