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Tryptophan 2,3‐dioxygenase in tumor cells is associated with resistance to immunotherapy in renal cell carcinoma

Indoleamine 2,3‐dioxygenase 1 (IDO1) is a key enzyme associated with immunomodulation through its regulation of the tryptophan‐kynurenine (Kyn) pathway in advanced cancers, including metastatic renal cell carcinoma (mRCC). However, the failure of IDO1 inhibitors when used in combination with immune...

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Detalles Bibliográficos
Autores principales:	Sumitomo, Makoto, Takahara, Kiyoshi, Zennami, Kenji, Nagakawa, Tomomi, Maeda, Yasuhiro, Shiogama, Kazuya, Yamamoto, Yasuko, Muto, Yoshinari, Nukaya, Takuhisa, Takenaka, Masashi, Fukaya, Kosuke, Ichino, Manabu, Sasaki, Hitomi, Saito, Kuniaki, Shiroki, Ryoichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935775/ https://www.ncbi.nlm.nih.gov/pubmed/33410234 http://dx.doi.org/10.1111/cas.14797

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