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Limitations and benefits of FDG‐PET/CT in NF1 patients with nerve sheath tumors: A cross‐sectional/longitudinal study
The purposes of this study were to re‐confirm the usefulness of PET/CT in the differentiation of benignity/malignancy of neurogenic tumors in NF1 patients, and to analyze the natural course of plexiform neurofibroma (pNF) and clarify whether PET/CT is also useful for detecting tumors other than neur...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935790/ https://www.ncbi.nlm.nih.gov/pubmed/33415792 http://dx.doi.org/10.1111/cas.14802 |
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author | Nishida, Yoshihiro Ikuta, Kunihiro Ito, Shinji Urakawa, Hiroshi Sakai, Tomohisa Koike, Hiroshi Ito, Kan Imagama, Shiro |
author_facet | Nishida, Yoshihiro Ikuta, Kunihiro Ito, Shinji Urakawa, Hiroshi Sakai, Tomohisa Koike, Hiroshi Ito, Kan Imagama, Shiro |
author_sort | Nishida, Yoshihiro |
collection | PubMed |
description | The purposes of this study were to re‐confirm the usefulness of PET/CT in the differentiation of benignity/malignancy of neurogenic tumors in NF1 patients, and to analyze the natural course of plexiform neurofibroma (pNF) and clarify whether PET/CT is also useful for detecting tumors other than neurogenic tumors. PET/CT was prospectively imaged in 36 NF1 patients. There were 14 malignant peripheral nerve sheath tumors (MPNSTs) in 14 patients, and 54 pNFs in 30 patients. Nine patients had both MPNST and pNF. Maximal standardized uptake value (SUVmax) was significantly higher in MPNST (median 7.6: range 4.1‐10.4) (P < .001) compared with that of pNF (median 3.7: range 1.6‐9.3). The cut‐off value of 5.8 resulted in a sensitivity of 78.6% and specificity of 88.9%. Median age was 29 y, and median maximum tumor diameter was 82 mm in 14 MPNST patients. The 5‐y overall survival rate was 46.8%. Three patients with low‐grade MPNST were alive without disease at the time of this report. In 9 patients in which pNF and MPNST co‐existed, 2 showed a higher SUVmax of pNF than that of MPNST. Natural history analysis of pNF (n = 43) revealed that no factors significantly correlated with increased tumor size. Nine lesions other than neurogenic tumors were detected by PET/CT including 5 thyroid lesions and 3 malignant neoplasms. This study revealed the usefulness and limitation of PET/CT for NF1 patients. In the future, it will be necessary to study how to detect over time the malignant transformation of pNF to MPNST, via an intermediate tumor. |
format | Online Article Text |
id | pubmed-7935790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79357902021-03-15 Limitations and benefits of FDG‐PET/CT in NF1 patients with nerve sheath tumors: A cross‐sectional/longitudinal study Nishida, Yoshihiro Ikuta, Kunihiro Ito, Shinji Urakawa, Hiroshi Sakai, Tomohisa Koike, Hiroshi Ito, Kan Imagama, Shiro Cancer Sci Original Articles The purposes of this study were to re‐confirm the usefulness of PET/CT in the differentiation of benignity/malignancy of neurogenic tumors in NF1 patients, and to analyze the natural course of plexiform neurofibroma (pNF) and clarify whether PET/CT is also useful for detecting tumors other than neurogenic tumors. PET/CT was prospectively imaged in 36 NF1 patients. There were 14 malignant peripheral nerve sheath tumors (MPNSTs) in 14 patients, and 54 pNFs in 30 patients. Nine patients had both MPNST and pNF. Maximal standardized uptake value (SUVmax) was significantly higher in MPNST (median 7.6: range 4.1‐10.4) (P < .001) compared with that of pNF (median 3.7: range 1.6‐9.3). The cut‐off value of 5.8 resulted in a sensitivity of 78.6% and specificity of 88.9%. Median age was 29 y, and median maximum tumor diameter was 82 mm in 14 MPNST patients. The 5‐y overall survival rate was 46.8%. Three patients with low‐grade MPNST were alive without disease at the time of this report. In 9 patients in which pNF and MPNST co‐existed, 2 showed a higher SUVmax of pNF than that of MPNST. Natural history analysis of pNF (n = 43) revealed that no factors significantly correlated with increased tumor size. Nine lesions other than neurogenic tumors were detected by PET/CT including 5 thyroid lesions and 3 malignant neoplasms. This study revealed the usefulness and limitation of PET/CT for NF1 patients. In the future, it will be necessary to study how to detect over time the malignant transformation of pNF to MPNST, via an intermediate tumor. John Wiley and Sons Inc. 2021-01-22 2021-03 /pmc/articles/PMC7935790/ /pubmed/33415792 http://dx.doi.org/10.1111/cas.14802 Text en © 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Nishida, Yoshihiro Ikuta, Kunihiro Ito, Shinji Urakawa, Hiroshi Sakai, Tomohisa Koike, Hiroshi Ito, Kan Imagama, Shiro Limitations and benefits of FDG‐PET/CT in NF1 patients with nerve sheath tumors: A cross‐sectional/longitudinal study |
title | Limitations and benefits of FDG‐PET/CT in NF1 patients with nerve sheath tumors: A cross‐sectional/longitudinal study |
title_full | Limitations and benefits of FDG‐PET/CT in NF1 patients with nerve sheath tumors: A cross‐sectional/longitudinal study |
title_fullStr | Limitations and benefits of FDG‐PET/CT in NF1 patients with nerve sheath tumors: A cross‐sectional/longitudinal study |
title_full_unstemmed | Limitations and benefits of FDG‐PET/CT in NF1 patients with nerve sheath tumors: A cross‐sectional/longitudinal study |
title_short | Limitations and benefits of FDG‐PET/CT in NF1 patients with nerve sheath tumors: A cross‐sectional/longitudinal study |
title_sort | limitations and benefits of fdg‐pet/ct in nf1 patients with nerve sheath tumors: a cross‐sectional/longitudinal study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935790/ https://www.ncbi.nlm.nih.gov/pubmed/33415792 http://dx.doi.org/10.1111/cas.14802 |
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