Pathogenicity assessment of variants for breast cancer susceptibility genes based on BRCAness of tumor sample

Genes involved in the homologous recombination repair pathway—as exemplified by BRCA1, BRCA2, PALB2, ATM, and CHEK2—are frequently associated with hereditary breast and ovarian cancer syndrome. Germline mutations in the loci of these genes with loss of heterozygosity or additional somatic truncation...

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Detalles Bibliográficos
Autores principales: Yoshida, Reiko, Hagio, Taichi, Kaneyasu, Tomoko, Gotoh, Osamu, Osako, Tomo, Tanaka, Norio, Amino, Sayuri, Yaguchi, Noriko, Nakashima, Eri, Kitagawa, Dai, Ueno, Takayuki, Ohno, Shinji, Nakajima, Takeshi, Nakamura, Seigo, Miki, Yoshio, Hirota, Toru, Takahashi, Shunji, Matsuura, Masaaki, Noda, Tetsuo, Mori, Seiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935793/
https://www.ncbi.nlm.nih.gov/pubmed/33421217
http://dx.doi.org/10.1111/cas.14803

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