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Targeting the mutant PIK3CA gene by DNA‐alkylating pyrrole‐imidazole polyamide in cervical cancer

PIK3CA is the most frequently mutated oncogene in cervical cancer, and somatic mutations in the PIK3CA gene result in increased activity of PI3K. In cervical cancer, the E545K mutation in PIK3CA leads to elevated cell proliferation and reduced apoptosis. In the present study, we designed and synthes...

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Detalles Bibliográficos
Autores principales:	Krishnamurthy, Sakthisri, Yoda, Hiroyuki, Hiraoka, Kiriko, Inoue, Takahiro, Lin, Jason, Shinozaki, Yoshinao, Watanabe, Takayoshi, Koshikawa, Nobuko, Takatori, Atsushi, Nagase, Hiroki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935806/ https://www.ncbi.nlm.nih.gov/pubmed/33377228 http://dx.doi.org/10.1111/cas.14785

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