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Incidence, preventability, and causality of adverse drug reactions at a university hospital emergency department
PURPOSE: To investigate the characteristics of ADRs in patients admitting at the emergency room of a tertiary hospital. METHODS: We collected the patient records of 1600 emergency room visits of a university hospital in 2018. The patient files were studied retrospectively and all possible ADRs were...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935812/ https://www.ncbi.nlm.nih.gov/pubmed/33188450 http://dx.doi.org/10.1007/s00228-020-03043-3 |
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author | Kauppila, Mirjam Backman, Janne T. Niemi, Mikko Lapatto-Reiniluoto, Outi |
author_facet | Kauppila, Mirjam Backman, Janne T. Niemi, Mikko Lapatto-Reiniluoto, Outi |
author_sort | Kauppila, Mirjam |
collection | PubMed |
description | PURPOSE: To investigate the characteristics of ADRs in patients admitting at the emergency room of a tertiary hospital. METHODS: We collected the patient records of 1600 emergency room visits of a university hospital in 2018. The patient files were studied retrospectively and all possible ADRs were identified and registered. Patient characteristics, drugs associated with ADRs, causality, severity, preventability, and the role of pharmacogenetics were assessed. RESULTS: There were 125 cases with ADRs, resulting in a 7.8% overall incidence among emergency visits. The incidence was greatest in visits among elderly patients, reaching 14% (men) to 19% (women) in the 80–89 years age group. The most common causative drugs were warfarin, acetylsalicylic acid (ASA), apixaban, and docetaxel, and the most common ADRs were bleedings and neutropenia and/or severe infections. Only two of the cases might have been prevented by pharmacogenetic testing, as advised in Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines. CONCLUSION: The same ATC classes, antithrombotics and cytostatics, were involved in ADRs causing university clinic hospitalizations as those identified previously in drug-related hospital fatalities. It seems difficult to prevent these events totally, as the treatments are vitally important and their risk-benefit-relationships have been considered thoroughly, and as pharmacogenetic testing could have been useful in only few cases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00228-020-03043-3. |
format | Online Article Text |
id | pubmed-7935812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-79358122021-03-19 Incidence, preventability, and causality of adverse drug reactions at a university hospital emergency department Kauppila, Mirjam Backman, Janne T. Niemi, Mikko Lapatto-Reiniluoto, Outi Eur J Clin Pharmacol Pharmacoepidemiology and Prescription PURPOSE: To investigate the characteristics of ADRs in patients admitting at the emergency room of a tertiary hospital. METHODS: We collected the patient records of 1600 emergency room visits of a university hospital in 2018. The patient files were studied retrospectively and all possible ADRs were identified and registered. Patient characteristics, drugs associated with ADRs, causality, severity, preventability, and the role of pharmacogenetics were assessed. RESULTS: There were 125 cases with ADRs, resulting in a 7.8% overall incidence among emergency visits. The incidence was greatest in visits among elderly patients, reaching 14% (men) to 19% (women) in the 80–89 years age group. The most common causative drugs were warfarin, acetylsalicylic acid (ASA), apixaban, and docetaxel, and the most common ADRs were bleedings and neutropenia and/or severe infections. Only two of the cases might have been prevented by pharmacogenetic testing, as advised in Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines. CONCLUSION: The same ATC classes, antithrombotics and cytostatics, were involved in ADRs causing university clinic hospitalizations as those identified previously in drug-related hospital fatalities. It seems difficult to prevent these events totally, as the treatments are vitally important and their risk-benefit-relationships have been considered thoroughly, and as pharmacogenetic testing could have been useful in only few cases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00228-020-03043-3. Springer Berlin Heidelberg 2020-11-13 2021 /pmc/articles/PMC7935812/ /pubmed/33188450 http://dx.doi.org/10.1007/s00228-020-03043-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Pharmacoepidemiology and Prescription Kauppila, Mirjam Backman, Janne T. Niemi, Mikko Lapatto-Reiniluoto, Outi Incidence, preventability, and causality of adverse drug reactions at a university hospital emergency department |
title | Incidence, preventability, and causality of adverse drug reactions at a university hospital emergency department |
title_full | Incidence, preventability, and causality of adverse drug reactions at a university hospital emergency department |
title_fullStr | Incidence, preventability, and causality of adverse drug reactions at a university hospital emergency department |
title_full_unstemmed | Incidence, preventability, and causality of adverse drug reactions at a university hospital emergency department |
title_short | Incidence, preventability, and causality of adverse drug reactions at a university hospital emergency department |
title_sort | incidence, preventability, and causality of adverse drug reactions at a university hospital emergency department |
topic | Pharmacoepidemiology and Prescription |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935812/ https://www.ncbi.nlm.nih.gov/pubmed/33188450 http://dx.doi.org/10.1007/s00228-020-03043-3 |
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