Type 2 Diabetes Mellitus and Vertebral Fracture Risk

PURPOSE OF REVIEW: The purpose of this review is to summarize the recently published evidence concerning vertebral fracture risk in individuals with diabetes mellitus. RECENT FINDINGS: Vertebral fracture risk is increased in individuals with T2DM. The presence of vertebral fractures in T2DM is assoc...

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Autores principales: Koromani, Fjorda, Ghatan, Samuel, van Hoek, Mandy, Zillikens, M. Carola, Oei, Edwin H. G., Rivadeneira, Fernando, Oei, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Bone and Diabetes (A Schwartz and P Vestergaard, Section Editors)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935814/
https://www.ncbi.nlm.nih.gov/pubmed/33432548
http://dx.doi.org/10.1007/s11914-020-00646-8
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author Koromani, Fjorda
Ghatan, Samuel
van Hoek, Mandy
Zillikens, M. Carola
Oei, Edwin H. G.
Rivadeneira, Fernando
Oei, Ling
author_facet Koromani, Fjorda
Ghatan, Samuel
van Hoek, Mandy
Zillikens, M. Carola
Oei, Edwin H. G.
Rivadeneira, Fernando
Oei, Ling
author_sort Koromani, Fjorda
collection PubMed
description PURPOSE OF REVIEW: The purpose of this review is to summarize the recently published evidence concerning vertebral fracture risk in individuals with diabetes mellitus. RECENT FINDINGS: Vertebral fracture risk is increased in individuals with T2DM. The presence of vertebral fractures in T2DM is associated with increased non-vertebral fracture risk and mortality. TBS could be helpful to estimate vertebral fracture risk in individuals with T2DM. An increased amount of bone marrow fat has been implicated in bone fragility in T2DM. Results from two recent studies show that both teriparatide and denosumab are effective in reducing vertebral fracture risk also in individuals with T2DM. SUMMARY: Individuals with T2DM could benefit from systematic screening in the clinic for presence of vertebral fractures.
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spelling pubmed-79358142021-03-19 Type 2 Diabetes Mellitus and Vertebral Fracture Risk Koromani, Fjorda Ghatan, Samuel van Hoek, Mandy Zillikens, M. Carola Oei, Edwin H. G. Rivadeneira, Fernando Oei, Ling Curr Osteoporos Rep Bone and Diabetes (A Schwartz and P Vestergaard, Section Editors) PURPOSE OF REVIEW: The purpose of this review is to summarize the recently published evidence concerning vertebral fracture risk in individuals with diabetes mellitus. RECENT FINDINGS: Vertebral fracture risk is increased in individuals with T2DM. The presence of vertebral fractures in T2DM is associated with increased non-vertebral fracture risk and mortality. TBS could be helpful to estimate vertebral fracture risk in individuals with T2DM. An increased amount of bone marrow fat has been implicated in bone fragility in T2DM. Results from two recent studies show that both teriparatide and denosumab are effective in reducing vertebral fracture risk also in individuals with T2DM. SUMMARY: Individuals with T2DM could benefit from systematic screening in the clinic for presence of vertebral fractures. Springer US 2021-01-12 2021 /pmc/articles/PMC7935814/ /pubmed/33432548 http://dx.doi.org/10.1007/s11914-020-00646-8 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Bone and Diabetes (A Schwartz and P Vestergaard, Section Editors)
Koromani, Fjorda
Ghatan, Samuel
van Hoek, Mandy
Zillikens, M. Carola
Oei, Edwin H. G.
Rivadeneira, Fernando
Oei, Ling
Type 2 Diabetes Mellitus and Vertebral Fracture Risk
title Type 2 Diabetes Mellitus and Vertebral Fracture Risk
title_full Type 2 Diabetes Mellitus and Vertebral Fracture Risk
title_fullStr Type 2 Diabetes Mellitus and Vertebral Fracture Risk
title_full_unstemmed Type 2 Diabetes Mellitus and Vertebral Fracture Risk
title_short Type 2 Diabetes Mellitus and Vertebral Fracture Risk
title_sort type 2 diabetes mellitus and vertebral fracture risk
topic Bone and Diabetes (A Schwartz and P Vestergaard, Section Editors)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935814/
https://www.ncbi.nlm.nih.gov/pubmed/33432548
http://dx.doi.org/10.1007/s11914-020-00646-8
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