Cargando…

Proteomics of REPLICANT perfusate detects changes in the metastatic lymph node microenvironment

In breast cancer (BC), detecting low volumes of axillary lymph node (ALN) metastasis pre-operatively is difficult and novel biomarkers are needed. We recently showed that patient-derived ALNs can be sustained ex-vivo using normothermic perfusion. We now compare reactive (tumour-free; n = 5) and macr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stevenson, Julia, Barrow-McGee, Rachel, Yu, Lu, Paul, Angela, Mansfield, David, Owen, Julie, Woodman, Natalie, Natrajan, Rachael, Haider, Syed, Gillett, Cheryl, Tutt, Andrew, Pinder, Sarah E., Choudary, Jyoti, Naidoo, Kalnisha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935848/ https://www.ncbi.nlm.nih.gov/pubmed/33674617 http://dx.doi.org/10.1038/s41523-021-00227-7

Ejemplares similares

Real‐time ex vivo perfusion of human lymph nodes invaded by cancer (REPLICANT): a feasibility study
por: Barrow‐McGee, Rachel, et al.
Publicado: (2019)

Histological scoring of immune and stromal features in breast and axillary lymph nodes is prognostic for distant metastasis in lymph node‐positive breast cancers
por: Grigoriadis, Anita, et al.
Publicado: (2018)

Assessment of the Molecular Heterogeneity of E-Cadherin Expression in Invasive Lobular Breast Cancer
por: Alexander, John, et al.
Publicado: (2022)

Dynamic Changes in the NK-, Neutrophil-, and B-cell Immunophenotypes Relevant in High Metastatic Risk Post Neoadjuvant Chemotherapy–Resistant Early Breast Cancers
por: Gazinska, Patrycja, et al.
Publicado: (2022)

Inflammation and Tumor Microenvironment in Lymph Node Metastasis
por: Wu, Xuesong, et al.
Publicado: (2011)

Chemokine-Releasing Nanoparticles for Manipulation of the Lymph Node Microenvironment
por: Popova, Taissia G., et al.
Publicado: (2015)

Benign lymph node microenvironment is associated with response to immunotherapy
por: Toki, Maria I, et al.
Publicado: (2020)

Optimised ARID1A immunohistochemistry is an accurate predictor of ARID1A mutational status in gynaecological cancers
por: Khalique, Saira, et al.
Publicado: (2018)

Splicing imbalances in basal-like breast cancer underpin perturbation of cell surface and oncogenic pathways and are associated with patients’ survival
por: Gracio, Filipe, et al.
Publicado: (2017)

Harnessing Biomaterials to Engineer the Lymph Node Microenvironment for Immunity or Tolerance
por: Andorko, James I., et al.
Publicado: (2014)

Reprogramming of sentinel lymph node microenvironment during tumor metastasis
por: Li, Yen-Liang, et al.
Publicado: (2022)

Utility of SPECT/CT in Sentinel Lymph Node Detection in a Case of Vulvar Carcinoma
por: Balasubramanian Harisankar, Chidambaram Natrajan, et al.
Publicado: (2013)

Tolerogenic Properties of Lymphatic Endothelial Cells Are Controlled by the Lymph Node Microenvironment
por: Cohen, Jarish N., et al.
Publicado: (2014)

The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation
por: Knoblich, Konstantin, et al.
Publicado: (2018)

Comparative Immunohistochemical Analysis of Ochratoxin A Tumourigenesis in Rats and Urinary Tract Carcinoma in Humans; Mechanistic Significance of p-S6 Ribosomal Protein Expression
por: Gazinska, Patrycja, et al.
Publicado: (2012)

Integrated genomic analysis of triple-negative breast cancers reveals novel microRNAs associated with clinical and molecular phenotypes and sheds light on the pathways they control
por: de Rinaldis, Emanuele, et al.
Publicado: (2013)

The value of immunohistochemistry in sentinel lymph node histopathology in breast cancer
por: Klevesath, M B, et al.
Publicado: (2005)

FIXATION OF NEURAL TISSUES FOR ELECTRON MICROSCOPY BY PERFUSION WITH SOLUTIONS OF OSMIUM TETROXIDE
por: Palay, Sanford L., et al.
Publicado: (1962)

Microenvironment of Tumor-Draining Lymph Nodes: Opportunities for Liposome-Based Targeted Therapy
por: Chandrasekaran, Siddarth, et al.
Publicado: (2014)

Characterization of the Microenvironment in Positive and Negative Sentinel Lymph Nodes from Melanoma Patients
por: Messaoudene, Meriem, et al.
Publicado: (2015)

Programming the lymph node microenvironment to enhance anti-tumor T cell immunity in neuroblastoma
por: Gammon, Joshua M, et al.
Publicado: (2015)

Tumor Immune Microenvironment Characterization of Primary Lung Adenocarcinoma and Lymph Node Metastases
por: Zhou, Yuan, et al.
Publicado: (2021)

The Lymph Node Microenvironment May Invigorate Cancer Cells With Enhanced Metastatic Capacities
por: Li, Tianhang, et al.
Publicado: (2022)

Characterisation of the Stromal Microenvironment in Lobular Breast Cancer
por: Gómez-Cuadrado, Laura, et al.
Publicado: (2022)

Assessment of structural chromosomal instability phenotypes as biomarkers of carboplatin response in triple negative breast cancer: the TNT trial
por: Sipos, O., et al.
Publicado: (2021)

Evaluation of cervical lymph nodes with CT perfusion in patients with hypopharyngeal and laryngeal squamous cell cancer
por: Trojanowski, Piotr, et al.
Publicado: (2011)

A tumor microenvironment preoperative nomogram for prediction of lymph node metastasis in bladder cancer
por: Chen, Zhenghao, et al.
Publicado: (2022)

Immune-cancer interactions in tumors and tumor-draining lymph nodes: Novel prognostic indicators for breast cancer
por: Mansfield, James, et al.
Publicado: (2014)

Occurrence and prognosis of lymph node metastases in patients selected for isolated limb perfusion with soft tissue sarcoma
por: Crettenand, François, et al.
Publicado: (2018)

Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype
por: Beatson, Richard, et al.
Publicado: (2020)

Microenvironment components and spatially resolved single-cell transcriptome atlas of breast cancer metastatic axillary lymph nodes: The lymph node atlas of breast cancer metastases
por: Xu, Kun, et al.
Publicado: (2022)

Immunosuppressive Features of the Microenvironment in Lymph Nodes Granulomas from Tuberculosis and HIV–Co-Infected Patients
por: Ashenafi, Senait, et al.
Publicado: (2022)

P1218: A REPROGRAMMING OF THE LYMPH NODE MICROENVIRONMENT UNDERLIES LOSS OF COMPARTMENTALISATION IN AGGRESSIVE LYMPHOMAS
por: Mathioudaki, Anna, et al.
Publicado: (2023)

Cancer stem cells promote lymph nodes metastasis of breast cancer by reprogramming tumor microenvironment
por: Li, Lin, et al.
Publicado: (2023)

An Interesting Case of Retropharyngeal Lymph Nodal Metastases in a Case of Iodine-Refractory Thyroid Cancer
por: Harisankar, Chidambaram Natrajan Balasubramanian, et al.
Publicado: (2018)

Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients
por: Chatterjee, Gaurav, et al.
Publicado: (2018)

Secretion of immunoglobulin by neoplastic B lymphocytes from lymph nodes of patients with lymphoma.
por: Stevenson, F. K., et al.
Publicado: (1984)

Accuracy of computed tomography perfusion in assessing metastatic involvement of enlarged axillary lymph nodes in patients with breast cancer
por: Liu, Yun, et al.
Publicado: (2007)

Oncological Outcomes in Rats Given Nephrocarcinogenic Exposure to Dietary Ochratoxin A, Followed by the Tumour Promoter Sodium Barbital for Life: A Pilot Study
por: Mantle, Peter G., et al.
Publicado: (2010)

Comparison of Epicardial Fat Volume between Patients with Normal Perfusion and Reversible Perfusion Abnormalities on Myocardial Perfusion Imaging
por: Kilambi, Yeseshvi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mufd3e8m737367qnakcu23smei