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Inherently confinable split-drive systems in Drosophila

CRISPR-based gene-drive systems, which copy themselves via gene conversion mediated by the homology-directed repair (HDR) pathway, have the potential to revolutionize vector control. However, mutant alleles generated by the competing non-homologous end-joining (NHEJ) pathway, resistant to Cas9 cleav...

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Detalles Bibliográficos
Autores principales:	Terradas, Gerard, Buchman, Anna B., Bennett, Jared B., Shriner, Isaiah, Marshall, John M., Akbari, Omar S., Bier, Ethan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935863/ https://www.ncbi.nlm.nih.gov/pubmed/33674604 http://dx.doi.org/10.1038/s41467-021-21771-7

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