The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma

FGF19/FGFR4 autocrine signaling is one of the main targets for multi-kinase inhibitors (MKIs). However, the molecular mechanisms underlying FGF19/FGFR4 signaling in the antitumor effects to MKIs in hepatocellular carcinoma (HCC) remain unclear. In this study, the impact of FGFR4/ERK signaling inhibi...

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Detalles Bibliográficos
Autores principales: Kanzaki, Hiroaki, Chiba, Tetsuhiro, Ao, Junjie, Koroki, Keisuke, Kanayama, Kengo, Maruta, Susumu, Maeda, Takahiro, Kusakabe, Yuko, Kobayashi, Kazufumi, Kanogawa, Naoya, Kiyono, Soichiro, Nakamura, Masato, Kondo, Takayuki, Saito, Tomoko, Nakagawa, Ryo, Ogasawara, Sadahisa, Suzuki, Eiichiro, Ooka, Yoshihiko, Muroyama, Ryosuke, Nakamoto, Shingo, Yasui, Shin, Tawada, Akinobu, Arai, Makoto, Kanda, Tatsuo, Maruyama, Hitoshi, Mimura, Naoya, Kato, Jun, Zen, Yoh, Ohtsuka, Masayuki, Iwama, Atsushi, Kato, Naoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935880/
https://www.ncbi.nlm.nih.gov/pubmed/33674622
http://dx.doi.org/10.1038/s41598-021-84117-9

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