Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma

T-cell exhaustion denotes a hypofunctional state of T lymphocytes commonly found in cancer, but how tumor cells drive T-cell exhaustion remains elusive. Here, we find T-cell exhaustion linked to overall survival in 675 hepatocellular carcinoma (HCC) patients with diverse ethnicities and etiologies....

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Detalles Bibliográficos
Autores principales: Hung, Man Hsin, Lee, Joo Sang, Ma, Chi, Diggs, Laurence P., Heinrich, Sophia, Chang, Ching Wen, Ma, Lichun, Forgues, Marshonna, Budhu, Anuradha, Chaisaingmongkol, Jittiporn, Ruchirawat, Mathuros, Ruppin, Eytan, Greten, Tim F., Wang, Xin Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935900/
https://www.ncbi.nlm.nih.gov/pubmed/33674593
http://dx.doi.org/10.1038/s41467-021-21804-1

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