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The impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease
Data on the risk of breast cancer following a benign breast disease (BBD) diagnosis were derived predominantly from populations of women biopsied before the widespread use of mammographic screening and in whom these lesions were mostly incidental findings. Whether or not similar risk associations ar...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935945/ https://www.ncbi.nlm.nih.gov/pubmed/33674619 http://dx.doi.org/10.1038/s41523-021-00225-9 |
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author | Beca, Francisco Oh, Hannah Collins, Laura C. Tamimi, Rulla M. Schnitt, Stuart J. |
author_facet | Beca, Francisco Oh, Hannah Collins, Laura C. Tamimi, Rulla M. Schnitt, Stuart J. |
author_sort | Beca, Francisco |
collection | PubMed |
description | Data on the risk of breast cancer following a benign breast disease (BBD) diagnosis were derived predominantly from populations of women biopsied before the widespread use of mammographic screening and in whom these lesions were mostly incidental findings. Whether or not similar risk associations are seen when these lesions are detected in mammographically screened populations is unknown. To address this, we examined the variation in BBD and breast cancer risk associations by the calendar time of BBD diagnosis (pre- vs. post-mammography era [before vs. 1985 and after]) in a nested case–control study within the Nurses’ Health Study (NHS) and NHSII BBD subcohort (488 cases; 1908 controls). We performed logistic regression analysis, adjusting for matching factors and potential confounders, to estimate odds ratio (ORs) and 95% confidence interval (CI) for the association between BBD subtype (non-proliferative, proliferative without atypia, proliferative with atypical hyperplasia (AH)) and subsequent breast cancer risk. When compared with non-proliferative lesions, both proliferative lesions without atypia (PWA) and AHs were associated with similar levels of risk in the pre-mammographic (pre) and post-mammographic (post) time periods (PWA: OR [95% CI] = 1.73 [1.27, 2.36] pre vs. 1.12 [0.73, 1.74] post; AH: 4.41 [2.90, 6.70] pre vs. 3.69 [2.21, 6.15] post). The interaction by mammography era was not statistically significant (p-interaction = 0.47). These results suggest that the risk associations reported for BBD subtypes in the pre-mammography era remain valid for BBD detected after the widespread implementation of mammographic screening. |
format | Online Article Text |
id | pubmed-7935945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79359452021-03-19 The impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease Beca, Francisco Oh, Hannah Collins, Laura C. Tamimi, Rulla M. Schnitt, Stuart J. NPJ Breast Cancer Article Data on the risk of breast cancer following a benign breast disease (BBD) diagnosis were derived predominantly from populations of women biopsied before the widespread use of mammographic screening and in whom these lesions were mostly incidental findings. Whether or not similar risk associations are seen when these lesions are detected in mammographically screened populations is unknown. To address this, we examined the variation in BBD and breast cancer risk associations by the calendar time of BBD diagnosis (pre- vs. post-mammography era [before vs. 1985 and after]) in a nested case–control study within the Nurses’ Health Study (NHS) and NHSII BBD subcohort (488 cases; 1908 controls). We performed logistic regression analysis, adjusting for matching factors and potential confounders, to estimate odds ratio (ORs) and 95% confidence interval (CI) for the association between BBD subtype (non-proliferative, proliferative without atypia, proliferative with atypical hyperplasia (AH)) and subsequent breast cancer risk. When compared with non-proliferative lesions, both proliferative lesions without atypia (PWA) and AHs were associated with similar levels of risk in the pre-mammographic (pre) and post-mammographic (post) time periods (PWA: OR [95% CI] = 1.73 [1.27, 2.36] pre vs. 1.12 [0.73, 1.74] post; AH: 4.41 [2.90, 6.70] pre vs. 3.69 [2.21, 6.15] post). The interaction by mammography era was not statistically significant (p-interaction = 0.47). These results suggest that the risk associations reported for BBD subtypes in the pre-mammography era remain valid for BBD detected after the widespread implementation of mammographic screening. Nature Publishing Group UK 2021-03-05 /pmc/articles/PMC7935945/ /pubmed/33674619 http://dx.doi.org/10.1038/s41523-021-00225-9 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Beca, Francisco Oh, Hannah Collins, Laura C. Tamimi, Rulla M. Schnitt, Stuart J. The impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease |
title | The impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease |
title_full | The impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease |
title_fullStr | The impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease |
title_full_unstemmed | The impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease |
title_short | The impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease |
title_sort | impact of mammographic screening on the subsequent breast cancer risk associated with biopsy-proven benign breast disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935945/ https://www.ncbi.nlm.nih.gov/pubmed/33674619 http://dx.doi.org/10.1038/s41523-021-00225-9 |
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