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Hyocholic acid species as novel biomarkers for metabolic disorders

Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...

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Autores principales: Zheng, Xiaojiao, Chen, Tianlu, Zhao, Aihua, Ning, Zhangchi, Kuang, Junliang, Wang, Shouli, You, Yijun, Bao, Yuqian, Ma, Xiaojing, Yu, Haoyong, Zhou, Jian, Jiang, Miao, Li, Mengci, Wang, Jieyi, Ma, Xiaohui, Zhou, Shuiping, Li, Yitao, Ge, Kun, Rajani, Cynthia, Xie, Guoxiang, Hu, Cheng, Guo, Yike, Lu, Aiping, Jia, Weiping, Jia, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935989/
https://www.ncbi.nlm.nih.gov/pubmed/33674561
http://dx.doi.org/10.1038/s41467-021-21744-w
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author Zheng, Xiaojiao
Chen, Tianlu
Zhao, Aihua
Ning, Zhangchi
Kuang, Junliang
Wang, Shouli
You, Yijun
Bao, Yuqian
Ma, Xiaojing
Yu, Haoyong
Zhou, Jian
Jiang, Miao
Li, Mengci
Wang, Jieyi
Ma, Xiaohui
Zhou, Shuiping
Li, Yitao
Ge, Kun
Rajani, Cynthia
Xie, Guoxiang
Hu, Cheng
Guo, Yike
Lu, Aiping
Jia, Weiping
Jia, Wei
author_facet Zheng, Xiaojiao
Chen, Tianlu
Zhao, Aihua
Ning, Zhangchi
Kuang, Junliang
Wang, Shouli
You, Yijun
Bao, Yuqian
Ma, Xiaojing
Yu, Haoyong
Zhou, Jian
Jiang, Miao
Li, Mengci
Wang, Jieyi
Ma, Xiaohui
Zhou, Shuiping
Li, Yitao
Ge, Kun
Rajani, Cynthia
Xie, Guoxiang
Hu, Cheng
Guo, Yike
Lu, Aiping
Jia, Weiping
Jia, Wei
author_sort Zheng, Xiaojiao
collection PubMed
description Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict the development of metabolic disorders. We find in the first cohort (n = 1107) that both obesity and diabetes are associated with lower serum concentrations of HCA species. A separate cohort study (n = 91) validates this finding and further reveals that individuals with pre-diabetes are associated with lower levels of HCA species in feces. Serum HCA levels increase in the patients after gastric bypass surgery (n = 38) and can predict the remission of diabetes two years after surgery. The results are replicated in two independent, prospective cohorts (n = 132 and n = 207), where serum HCA species are found to be strong predictors for metabolic disorders in 5 and 10 years, respectively. These findings underscore the association of HCA species with diabetes, and demonstrate the feasibility of using HCA profiles to assess the future risk of developing metabolic abnormalities.
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spelling pubmed-79359892021-03-21 Hyocholic acid species as novel biomarkers for metabolic disorders Zheng, Xiaojiao Chen, Tianlu Zhao, Aihua Ning, Zhangchi Kuang, Junliang Wang, Shouli You, Yijun Bao, Yuqian Ma, Xiaojing Yu, Haoyong Zhou, Jian Jiang, Miao Li, Mengci Wang, Jieyi Ma, Xiaohui Zhou, Shuiping Li, Yitao Ge, Kun Rajani, Cynthia Xie, Guoxiang Hu, Cheng Guo, Yike Lu, Aiping Jia, Weiping Jia, Wei Nat Commun Article Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict the development of metabolic disorders. We find in the first cohort (n = 1107) that both obesity and diabetes are associated with lower serum concentrations of HCA species. A separate cohort study (n = 91) validates this finding and further reveals that individuals with pre-diabetes are associated with lower levels of HCA species in feces. Serum HCA levels increase in the patients after gastric bypass surgery (n = 38) and can predict the remission of diabetes two years after surgery. The results are replicated in two independent, prospective cohorts (n = 132 and n = 207), where serum HCA species are found to be strong predictors for metabolic disorders in 5 and 10 years, respectively. These findings underscore the association of HCA species with diabetes, and demonstrate the feasibility of using HCA profiles to assess the future risk of developing metabolic abnormalities. Nature Publishing Group UK 2021-03-05 /pmc/articles/PMC7935989/ /pubmed/33674561 http://dx.doi.org/10.1038/s41467-021-21744-w Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zheng, Xiaojiao
Chen, Tianlu
Zhao, Aihua
Ning, Zhangchi
Kuang, Junliang
Wang, Shouli
You, Yijun
Bao, Yuqian
Ma, Xiaojing
Yu, Haoyong
Zhou, Jian
Jiang, Miao
Li, Mengci
Wang, Jieyi
Ma, Xiaohui
Zhou, Shuiping
Li, Yitao
Ge, Kun
Rajani, Cynthia
Xie, Guoxiang
Hu, Cheng
Guo, Yike
Lu, Aiping
Jia, Weiping
Jia, Wei
Hyocholic acid species as novel biomarkers for metabolic disorders
title Hyocholic acid species as novel biomarkers for metabolic disorders
title_full Hyocholic acid species as novel biomarkers for metabolic disorders
title_fullStr Hyocholic acid species as novel biomarkers for metabolic disorders
title_full_unstemmed Hyocholic acid species as novel biomarkers for metabolic disorders
title_short Hyocholic acid species as novel biomarkers for metabolic disorders
title_sort hyocholic acid species as novel biomarkers for metabolic disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935989/
https://www.ncbi.nlm.nih.gov/pubmed/33674561
http://dx.doi.org/10.1038/s41467-021-21744-w
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