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Multiple Primary Melanoma Incidence Trends Over Five Decades: A Nationwide Population-Based Study
BACKGROUND: Over the past decades, many regions have experienced a steady increase in the incidence of cutaneous melanoma. Here, we report on incidence trends for subsequent primary melanoma. METHODS: In this nationwide population-based study, patients diagnosed with a first primary cutaneous melano...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936055/ https://www.ncbi.nlm.nih.gov/pubmed/32577730 http://dx.doi.org/10.1093/jnci/djaa088 |
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author | Helgadottir, Hildur Isaksson, Karolin Fritz, Ildiko Ingvar, Christian Lapins, Jan Höiom, Veronica Newton-Bishop, Julia Olsson, Håkan |
author_facet | Helgadottir, Hildur Isaksson, Karolin Fritz, Ildiko Ingvar, Christian Lapins, Jan Höiom, Veronica Newton-Bishop, Julia Olsson, Håkan |
author_sort | Helgadottir, Hildur |
collection | PubMed |
description | BACKGROUND: Over the past decades, many regions have experienced a steady increase in the incidence of cutaneous melanoma. Here, we report on incidence trends for subsequent primary melanoma. METHODS: In this nationwide population-based study, patients diagnosed with a first primary cutaneous melanoma reported to the Swedish Cancer Registry were followed for up to 10 years for a diagnosis of subsequent primary melanoma. Patients were grouped with patients diagnosed with first melanoma in the same decade (1960s, 1970s, 1980s, 1990s, and 2000s, respectively). Frequencies, incidence rates (IRs), standardized incidence ratios (SIRs), and 95% confidence intervals (CIs) for second melanomas were calculated. All tests of statistical significance were 2-sided. RESULTS: Of patients with melanoma, 54 884 were included and 2469 were diagnosed, within 10 years, with subsequent melanomas. Over the 5 decades, there was a statistically significant steady increase in the frequency, IR, and SIR for second primary melanoma. For example, in the 1960s cohort, less than 1% (IR = 1.0, 95% CI = 0.5 to 1.7, and IR = 1.1, 95% CI = 0.5 to 1.9 per 1000 person-years in women and men, respectively) had second primary melanoma, and this rose to 6.4% (IR = 7.5, 95% CI = 6.8 to 8.3, per 1000 person-years) in the women and 7.9% (IR = 10.3, 95% CI = 9.3 to 11.2, per 1000 person-years) in the men in the 2000s cohort. This rise was seen independent of age, sex, invasiveness, or site of the melanoma. Further, in patients diagnosed with a second melanoma, the frequency of those having more than 2 melanomas increased statistically significantly and was 0.0% in the 1960s and rose to 18.0% in the 2000s (P < .001). CONCLUSIONS: This is the first study to evaluate and report on a rising trend for subsequent primary melanoma. Additional primary melanomas worsen the patients’ survival, and precautions are needed to turn this steep upgoing trend. |
format | Online Article Text |
id | pubmed-7936055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-79360552021-03-10 Multiple Primary Melanoma Incidence Trends Over Five Decades: A Nationwide Population-Based Study Helgadottir, Hildur Isaksson, Karolin Fritz, Ildiko Ingvar, Christian Lapins, Jan Höiom, Veronica Newton-Bishop, Julia Olsson, Håkan J Natl Cancer Inst Articles BACKGROUND: Over the past decades, many regions have experienced a steady increase in the incidence of cutaneous melanoma. Here, we report on incidence trends for subsequent primary melanoma. METHODS: In this nationwide population-based study, patients diagnosed with a first primary cutaneous melanoma reported to the Swedish Cancer Registry were followed for up to 10 years for a diagnosis of subsequent primary melanoma. Patients were grouped with patients diagnosed with first melanoma in the same decade (1960s, 1970s, 1980s, 1990s, and 2000s, respectively). Frequencies, incidence rates (IRs), standardized incidence ratios (SIRs), and 95% confidence intervals (CIs) for second melanomas were calculated. All tests of statistical significance were 2-sided. RESULTS: Of patients with melanoma, 54 884 were included and 2469 were diagnosed, within 10 years, with subsequent melanomas. Over the 5 decades, there was a statistically significant steady increase in the frequency, IR, and SIR for second primary melanoma. For example, in the 1960s cohort, less than 1% (IR = 1.0, 95% CI = 0.5 to 1.7, and IR = 1.1, 95% CI = 0.5 to 1.9 per 1000 person-years in women and men, respectively) had second primary melanoma, and this rose to 6.4% (IR = 7.5, 95% CI = 6.8 to 8.3, per 1000 person-years) in the women and 7.9% (IR = 10.3, 95% CI = 9.3 to 11.2, per 1000 person-years) in the men in the 2000s cohort. This rise was seen independent of age, sex, invasiveness, or site of the melanoma. Further, in patients diagnosed with a second melanoma, the frequency of those having more than 2 melanomas increased statistically significantly and was 0.0% in the 1960s and rose to 18.0% in the 2000s (P < .001). CONCLUSIONS: This is the first study to evaluate and report on a rising trend for subsequent primary melanoma. Additional primary melanomas worsen the patients’ survival, and precautions are needed to turn this steep upgoing trend. Oxford University Press 2020-06-24 /pmc/articles/PMC7936055/ /pubmed/32577730 http://dx.doi.org/10.1093/jnci/djaa088 Text en © The Author(s) 2020. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Articles Helgadottir, Hildur Isaksson, Karolin Fritz, Ildiko Ingvar, Christian Lapins, Jan Höiom, Veronica Newton-Bishop, Julia Olsson, Håkan Multiple Primary Melanoma Incidence Trends Over Five Decades: A Nationwide Population-Based Study |
title | Multiple Primary Melanoma Incidence Trends Over Five Decades: A Nationwide Population-Based Study |
title_full | Multiple Primary Melanoma Incidence Trends Over Five Decades: A Nationwide Population-Based Study |
title_fullStr | Multiple Primary Melanoma Incidence Trends Over Five Decades: A Nationwide Population-Based Study |
title_full_unstemmed | Multiple Primary Melanoma Incidence Trends Over Five Decades: A Nationwide Population-Based Study |
title_short | Multiple Primary Melanoma Incidence Trends Over Five Decades: A Nationwide Population-Based Study |
title_sort | multiple primary melanoma incidence trends over five decades: a nationwide population-based study |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936055/ https://www.ncbi.nlm.nih.gov/pubmed/32577730 http://dx.doi.org/10.1093/jnci/djaa088 |
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