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Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk
We evaluated the joint associations between a new 313-variant PRS (PRS(313)) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic re...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936056/ https://www.ncbi.nlm.nih.gov/pubmed/32359158 http://dx.doi.org/10.1093/jnci/djaa056 |
| _version_ | 1783661123870916608 |
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| author | Kapoor, Pooja Middha Mavaddat, Nasim Choudhury, Parichoy Pal Wilcox, Amber N Lindström, Sara Behrens, Sabine Michailidou, Kyriaki Dennis, Joe Bolla, Manjeet K Wang, Qin Jung, Audrey Abu-Ful, Zomoroda Ahearn, Thomas Andrulis, Irene L Anton-Culver, Hoda Arndt, Volker Aronson, Kristan J Auer, Paul L Freeman, Laura E Beane Becher, Heiko Beckmann, Matthias W Beeghly-Fadiel, Alicia Benitez, Javier Bernstein, Leslie Bojesen, Stig E Brauch, Hiltrud Brenner, Hermann Brüning, Thomas Cai, Qiuyin Campa, Daniele Canzian, Federico Carracedo, Angel Carter, Brian D Castelao, Jose E Chanock, Stephen J Chatterjee, Nilanjan Chenevix-Trench, Georgia Clarke, Christine L Couch, Fergus J Cox, Angela Cross, Simon S Czene, Kamila Dai, James Y Earp, H Shelton Ekici, Arif B Eliassen, A Heather Eriksson, Mikael Evans, D Gareth Fasching, Peter A Figueroa, Jonine Fritschi, Lin Gabrielson, Marike Gago-Dominguez, Manuela Gao, Chi Gapstur, Susan M Gaudet, Mia M Giles, Graham G González-Neira, Anna Guénel, Pascal Haeberle, Lothar Haiman, Christopher A Håkansson, Niclas Hall, Per Hamann, Ute Hatse, Sigrid Heyworth, Jane Holleczek, Bernd Hoover, Robert N Hopper, John L Howell, Anthony Hunter, David J John, Esther M Jones, Michael E Kaaks, Rudolf Keeman, Renske Kitahara, Cari M Ko, Yon-Dschun Koutros, Stella Kurian, Allison W Lambrechts, Diether Le Marchand, Loic Lee, Eunjung Lejbkowicz, Flavio Linet, Martha Lissowska, Jolanta Llaneza, Ana MacInnis, Robert J Martinez, Maria Elena Maurer, Tabea McLean, Catriona Neuhausen, Susan L Newman, William G Norman, Aaron O’Brien, Katie M Olshan, Andrew F Olson, Janet E Olsson, Håkan Orr, Nick Perou, Charles M Pita, Guillermo Polley, Eric C Prentice, Ross L Rennert, Gad Rennert, Hedy S Ruddy, Kathryn J Sandler, Dale P Saunders, Christobel Schoemaker, Minouk J Schöttker, Ben Schumacher, Fredrick Scott, Christopher Scott, Rodney J Shu, Xiao-Ou Smeets, Ann Southey, Melissa C Spinelli, John J Stone, Jennifer Swerdlow, Anthony J Tamimi, Rulla M Taylor, Jack A Troester, Melissa A Vachon, Celine M van Veen, Elke M Wang, Xiaoliang Weinberg, Clarice R Weltens, Caroline Willett, Walter Winham, Stacey J Wolk, Alicja Yang, Xiaohong R Zheng, Wei Ziogas, Argyrios Dunning, Alison M Pharoah, Paul D P Schmidt, Marjanka K Kraft, Peter Easton, Douglas F Milne, Roger L García-Closas, Montserrat Chang-Claude, Jenny |
| author_facet | Kapoor, Pooja Middha Mavaddat, Nasim Choudhury, Parichoy Pal Wilcox, Amber N Lindström, Sara Behrens, Sabine Michailidou, Kyriaki Dennis, Joe Bolla, Manjeet K Wang, Qin Jung, Audrey Abu-Ful, Zomoroda Ahearn, Thomas Andrulis, Irene L Anton-Culver, Hoda Arndt, Volker Aronson, Kristan J Auer, Paul L Freeman, Laura E Beane Becher, Heiko Beckmann, Matthias W Beeghly-Fadiel, Alicia Benitez, Javier Bernstein, Leslie Bojesen, Stig E Brauch, Hiltrud Brenner, Hermann Brüning, Thomas Cai, Qiuyin Campa, Daniele Canzian, Federico Carracedo, Angel Carter, Brian D Castelao, Jose E Chanock, Stephen J Chatterjee, Nilanjan Chenevix-Trench, Georgia Clarke, Christine L Couch, Fergus J Cox, Angela Cross, Simon S Czene, Kamila Dai, James Y Earp, H Shelton Ekici, Arif B Eliassen, A Heather Eriksson, Mikael Evans, D Gareth Fasching, Peter A Figueroa, Jonine Fritschi, Lin Gabrielson, Marike Gago-Dominguez, Manuela Gao, Chi Gapstur, Susan M Gaudet, Mia M Giles, Graham G González-Neira, Anna Guénel, Pascal Haeberle, Lothar Haiman, Christopher A Håkansson, Niclas Hall, Per Hamann, Ute Hatse, Sigrid Heyworth, Jane Holleczek, Bernd Hoover, Robert N Hopper, John L Howell, Anthony Hunter, David J John, Esther M Jones, Michael E Kaaks, Rudolf Keeman, Renske Kitahara, Cari M Ko, Yon-Dschun Koutros, Stella Kurian, Allison W Lambrechts, Diether Le Marchand, Loic Lee, Eunjung Lejbkowicz, Flavio Linet, Martha Lissowska, Jolanta Llaneza, Ana MacInnis, Robert J Martinez, Maria Elena Maurer, Tabea McLean, Catriona Neuhausen, Susan L Newman, William G Norman, Aaron O’Brien, Katie M Olshan, Andrew F Olson, Janet E Olsson, Håkan Orr, Nick Perou, Charles M Pita, Guillermo Polley, Eric C Prentice, Ross L Rennert, Gad Rennert, Hedy S Ruddy, Kathryn J Sandler, Dale P Saunders, Christobel Schoemaker, Minouk J Schöttker, Ben Schumacher, Fredrick Scott, Christopher Scott, Rodney J Shu, Xiao-Ou Smeets, Ann Southey, Melissa C Spinelli, John J Stone, Jennifer Swerdlow, Anthony J Tamimi, Rulla M Taylor, Jack A Troester, Melissa A Vachon, Celine M van Veen, Elke M Wang, Xiaoliang Weinberg, Clarice R Weltens, Caroline Willett, Walter Winham, Stacey J Wolk, Alicja Yang, Xiaohong R Zheng, Wei Ziogas, Argyrios Dunning, Alison M Pharoah, Paul D P Schmidt, Marjanka K Kraft, Peter Easton, Douglas F Milne, Roger L García-Closas, Montserrat Chang-Claude, Jenny |
| author_sort | Kapoor, Pooja Middha |
| collection | PubMed |
| description | We evaluated the joint associations between a new 313-variant PRS (PRS(313)) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression and a newly developed case-only method for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS(313) odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS(313) and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS(313) and family history) and, on average, 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer. |
| format | Online Article Text |
| id | pubmed-7936056 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-79360562021-03-10 Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk Kapoor, Pooja Middha Mavaddat, Nasim Choudhury, Parichoy Pal Wilcox, Amber N Lindström, Sara Behrens, Sabine Michailidou, Kyriaki Dennis, Joe Bolla, Manjeet K Wang, Qin Jung, Audrey Abu-Ful, Zomoroda Ahearn, Thomas Andrulis, Irene L Anton-Culver, Hoda Arndt, Volker Aronson, Kristan J Auer, Paul L Freeman, Laura E Beane Becher, Heiko Beckmann, Matthias W Beeghly-Fadiel, Alicia Benitez, Javier Bernstein, Leslie Bojesen, Stig E Brauch, Hiltrud Brenner, Hermann Brüning, Thomas Cai, Qiuyin Campa, Daniele Canzian, Federico Carracedo, Angel Carter, Brian D Castelao, Jose E Chanock, Stephen J Chatterjee, Nilanjan Chenevix-Trench, Georgia Clarke, Christine L Couch, Fergus J Cox, Angela Cross, Simon S Czene, Kamila Dai, James Y Earp, H Shelton Ekici, Arif B Eliassen, A Heather Eriksson, Mikael Evans, D Gareth Fasching, Peter A Figueroa, Jonine Fritschi, Lin Gabrielson, Marike Gago-Dominguez, Manuela Gao, Chi Gapstur, Susan M Gaudet, Mia M Giles, Graham G González-Neira, Anna Guénel, Pascal Haeberle, Lothar Haiman, Christopher A Håkansson, Niclas Hall, Per Hamann, Ute Hatse, Sigrid Heyworth, Jane Holleczek, Bernd Hoover, Robert N Hopper, John L Howell, Anthony Hunter, David J John, Esther M Jones, Michael E Kaaks, Rudolf Keeman, Renske Kitahara, Cari M Ko, Yon-Dschun Koutros, Stella Kurian, Allison W Lambrechts, Diether Le Marchand, Loic Lee, Eunjung Lejbkowicz, Flavio Linet, Martha Lissowska, Jolanta Llaneza, Ana MacInnis, Robert J Martinez, Maria Elena Maurer, Tabea McLean, Catriona Neuhausen, Susan L Newman, William G Norman, Aaron O’Brien, Katie M Olshan, Andrew F Olson, Janet E Olsson, Håkan Orr, Nick Perou, Charles M Pita, Guillermo Polley, Eric C Prentice, Ross L Rennert, Gad Rennert, Hedy S Ruddy, Kathryn J Sandler, Dale P Saunders, Christobel Schoemaker, Minouk J Schöttker, Ben Schumacher, Fredrick Scott, Christopher Scott, Rodney J Shu, Xiao-Ou Smeets, Ann Southey, Melissa C Spinelli, John J Stone, Jennifer Swerdlow, Anthony J Tamimi, Rulla M Taylor, Jack A Troester, Melissa A Vachon, Celine M van Veen, Elke M Wang, Xiaoliang Weinberg, Clarice R Weltens, Caroline Willett, Walter Winham, Stacey J Wolk, Alicja Yang, Xiaohong R Zheng, Wei Ziogas, Argyrios Dunning, Alison M Pharoah, Paul D P Schmidt, Marjanka K Kraft, Peter Easton, Douglas F Milne, Roger L García-Closas, Montserrat Chang-Claude, Jenny J Natl Cancer Inst Brief Communication We evaluated the joint associations between a new 313-variant PRS (PRS(313)) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression and a newly developed case-only method for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS(313) odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS(313) and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS(313) and family history) and, on average, 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer. Oxford University Press 2020-05-02 /pmc/articles/PMC7936056/ /pubmed/32359158 http://dx.doi.org/10.1093/jnci/djaa056 Text en © The Author(s) 2020. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Brief Communication Kapoor, Pooja Middha Mavaddat, Nasim Choudhury, Parichoy Pal Wilcox, Amber N Lindström, Sara Behrens, Sabine Michailidou, Kyriaki Dennis, Joe Bolla, Manjeet K Wang, Qin Jung, Audrey Abu-Ful, Zomoroda Ahearn, Thomas Andrulis, Irene L Anton-Culver, Hoda Arndt, Volker Aronson, Kristan J Auer, Paul L Freeman, Laura E Beane Becher, Heiko Beckmann, Matthias W Beeghly-Fadiel, Alicia Benitez, Javier Bernstein, Leslie Bojesen, Stig E Brauch, Hiltrud Brenner, Hermann Brüning, Thomas Cai, Qiuyin Campa, Daniele Canzian, Federico Carracedo, Angel Carter, Brian D Castelao, Jose E Chanock, Stephen J Chatterjee, Nilanjan Chenevix-Trench, Georgia Clarke, Christine L Couch, Fergus J Cox, Angela Cross, Simon S Czene, Kamila Dai, James Y Earp, H Shelton Ekici, Arif B Eliassen, A Heather Eriksson, Mikael Evans, D Gareth Fasching, Peter A Figueroa, Jonine Fritschi, Lin Gabrielson, Marike Gago-Dominguez, Manuela Gao, Chi Gapstur, Susan M Gaudet, Mia M Giles, Graham G González-Neira, Anna Guénel, Pascal Haeberle, Lothar Haiman, Christopher A Håkansson, Niclas Hall, Per Hamann, Ute Hatse, Sigrid Heyworth, Jane Holleczek, Bernd Hoover, Robert N Hopper, John L Howell, Anthony Hunter, David J John, Esther M Jones, Michael E Kaaks, Rudolf Keeman, Renske Kitahara, Cari M Ko, Yon-Dschun Koutros, Stella Kurian, Allison W Lambrechts, Diether Le Marchand, Loic Lee, Eunjung Lejbkowicz, Flavio Linet, Martha Lissowska, Jolanta Llaneza, Ana MacInnis, Robert J Martinez, Maria Elena Maurer, Tabea McLean, Catriona Neuhausen, Susan L Newman, William G Norman, Aaron O’Brien, Katie M Olshan, Andrew F Olson, Janet E Olsson, Håkan Orr, Nick Perou, Charles M Pita, Guillermo Polley, Eric C Prentice, Ross L Rennert, Gad Rennert, Hedy S Ruddy, Kathryn J Sandler, Dale P Saunders, Christobel Schoemaker, Minouk J Schöttker, Ben Schumacher, Fredrick Scott, Christopher Scott, Rodney J Shu, Xiao-Ou Smeets, Ann Southey, Melissa C Spinelli, John J Stone, Jennifer Swerdlow, Anthony J Tamimi, Rulla M Taylor, Jack A Troester, Melissa A Vachon, Celine M van Veen, Elke M Wang, Xiaoliang Weinberg, Clarice R Weltens, Caroline Willett, Walter Winham, Stacey J Wolk, Alicja Yang, Xiaohong R Zheng, Wei Ziogas, Argyrios Dunning, Alison M Pharoah, Paul D P Schmidt, Marjanka K Kraft, Peter Easton, Douglas F Milne, Roger L García-Closas, Montserrat Chang-Claude, Jenny Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk |
| title | Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk |
| title_full | Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk |
| title_fullStr | Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk |
| title_full_unstemmed | Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk |
| title_short | Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk |
| title_sort | combined associations of a polygenic risk score and classical risk factors with breast cancer risk |
| topic | Brief Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936056/ https://www.ncbi.nlm.nih.gov/pubmed/32359158 http://dx.doi.org/10.1093/jnci/djaa056 |
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troestermelissaa combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT vachoncelinem combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT vanveenelkem combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT wangxiaoliang combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT weinbergclaricer combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT weltenscaroline combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT willettwalter combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT winhamstaceyj combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT wolkalicja combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT yangxiaohongr combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT zhengwei combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT ziogasargyrios combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT dunningalisonm combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT pharoahpauldp combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT schmidtmarjankak combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT kraftpeter combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT eastondouglasf combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT milnerogerl combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT garciaclosasmontserrat combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk AT changclaudejenny combinedassociationsofapolygenicriskscoreandclassicalriskfactorswithbreastcancerrisk |