Generating tumor-selective conditionally active biologic anti-CTLA4 antibodies via protein-associated chemical switches

Anticytotoxic T lymphocyte-associated protein 4 (CTLA4) antibodies have shown potent antitumor activity, but systemic immune activation leads to severe immune-related adverse events, limiting clinical usage. We developed novel, conditionally active biologic (CAB) anti-CTLA4 antibodies that are activ...

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Detalles Bibliográficos
Autores principales: Chang, Hwai Wen, Frey, Gerhard, Liu, Haizhen, Xing, Charles, Steinman, Lawrence, Boyle, William J., Short, Jay M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936328/
https://www.ncbi.nlm.nih.gov/pubmed/33627407
http://dx.doi.org/10.1073/pnas.2020606118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936328/
https://www.ncbi.nlm.nih.gov/pubmed/33627407
http://dx.doi.org/10.1073/pnas.2020606118

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